Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

QR رمز

Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Background: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, we examined the timing of its effect on death. Methods: The CRASH-3 trial random...

وصف كامل

التفاصيل البيبلوغرافية
الحاوية / القاعدة:	Critical Care
المؤلف الرئيسي:	Brenner A.; Belli A.; Chaudhri R.; Coats T.; Frimley L.; Jamaluddin S.F.; Jooma R.; Mansukhani R.; Sandercock P.; Shakur-Still H.; Shokunbi T.; Roberts I.
التنسيق:	مقال
اللغة:	English
منشور في:	BioMed Central Ltd 2020
الوصول للمادة أونلاين:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095781531&doi=10.1186%2fs13054-020-03243-4&partnerID=40&md5=15c5815a3482e941f90ef01220ef9d47

مواد مشابهة

Effect of early tranexamic acid treatment on fatigue in patients with mild traumatic brain injury: data from the CRASH-3 clinical trial
بواسطة: Mansukhani R.; Belli A.; Brenner A.; Chaudhri R.; Frimley L.; Faizah Jamaluddin S.; Jooma R.; Shakur-Still H.; Shokunbi T.; Roberts I.
منشور في: (2024)

A partially randomised trial of pretomanid, moxifloxacin and pyrazinamide for pulmonary TB
بواسطة: Tweed C.D.; Wills G.H.; Crook A.M.; Amukoye E.; Balanag V.; Ban A.Y.L.; Bateson A.L.C.; Betteridge M.C.; Brumskine W.; Caoili J.; Chaisson R.E.; Cevik M.; Conradie F.; Dawson R.; del Parigi A.; Diacon A.; Everitt D.E.; Fabiane S.M.; Hunt R.; Ismail A.I.; Lalloo U.; Lombard L.; Louw C.; Malahleha M.; McHugh T.D.; Mendel C.M.; Mhimbira F.; Moodliar R.N.; Nduba V.; Nunn A.J.; Sabi I.; Sebe M.A.; Selepe R.A.P.; Staples S.; Swindells S.; van Niekerk C.H.; Variava E.; Spigelman M.; Gillespie S.H.
منشور في: (2021)

A partially randomised trial of pretomanid, moxifloxacin and pyrazinamide for pulmonary TB
بواسطة: 2-s2.0-85103500407
منشور في: (2021)

Exploratory Structural Modification and Nonlinear Based Analysis of Tuned Mass Dampers
بواسطة: Rousou K.; Abdul Rani M.N.; Bahari A.R.; Kyprianou A.
منشور في: (2024)

Injury severity among non-fatal children and adults related to motorcycle crashes
بواسطة: Faudzi S.A.M.; Zulkipli Z.H.; Wahid N.A.A.
منشور في: (2016)

Crash Investigation on Frontal Vehicle Chassis Frame using Finite Element Simulation
بواسطة: 2-s2.0-85141464799
منشور في: (2022)

Injury severity among non-fatal children and adults related to motorcycle crashes
بواسطة: 2-s2.0-85106851168
منشور في: (2016)

A community-based comprehensive intervention to reduce cardiovascular risk in hypertension (HOPE 4): a cluster-randomised controlled trial
بواسطة: 2-s2.0-85072785863
منشور في: (2019)

Empowering decision-making in cardiovascular care: Exploratory data analysis and predictive models for heart attack risk
بواسطة: Khan M.R.B.; Islam G.M.N.; Ng P.K.; Zainuddin A.A.; Lean C.P.; Al-Fattah J.; Kamarudin S.I.
منشور في: (2024)

The application of hibah al-ʿumra in disbursement of family Takāful benefits: an exploratory study
بواسطة: Rahman M.H.; Abdullah M.F.; Hoque M.N.; Ahmad A.U.F.
منشور في: (2023)

A comparison of characteristics between food delivery riders with and without traffic crash experience during delivery in Malaysia
بواسطة: 2-s2.0-85140084573
منشور في: (2022)

A single-blind, randomised control trial on the effectiveness of a structured multi component training module for family caregiver of persons with Parkinson's disease: A study protocol
بواسطة: Mohd Amin, وآخرون
منشور في: (2024)

The effects of self-efficacy enhancing program on foot self-care behaviour of older adults with diabetes: A randomised controlled trial in elderly care facility, Peninsular Malaysia
بواسطة: 2-s2.0-85043756873
منشور في: (2018)

Assessing the Relationship of Skills and Performance: An Exploratory Study of Religious Based Cooperatives’ Board Members
بواسطة: Abdullah Salim A.S.; Mustafa M.A.; Yatim N.M.; Masuod M.S.; Abu Said A.M.; Abdullah Sani N.
منشور في: (2024)

Barriers and enablers to adoption of cyber insurance in developing countries: An exploratory study of Malaysian organizations
بواسطة: 2-s2.0-85138051453
منشور في: (2022)

Randomised clinical trial: the effectiveness of Gaviscon Advance vs non-alginate antacid in suppression of acid pocket and post-prandial reflux in obese individuals after late-night supper
بواسطة: 2-s2.0-85084007878
منشور في: (2020)

Exploratory factor analysis: Blended motivation of Malay students Learning Mandarin as a Foreign Language
بواسطة: Tan T.G.; Ismail H.N.; Ooi A.E.
منشور في: (2016)

SPATIAL ANALYSIS OF ROAD TRAFFIC ACCIDENT HOTSPOTS AND PATTERNS IN MUSCAT, OMAN: AN EXPLORATORY RISK MANAGEMENT ASSESSMENT
بواسطة: 2-s2.0-85210931161
منشور في: (2024)

An exploratory study of industry 4.0 in Malaysia: A case study of higher education institution in Malaysia
بواسطة: 2-s2.0-85073613071
منشور في: (2019)

The immediate effect of traditional Malay massage on substance P, inflammatory mediators, pain scale and functional outcome among patients with low back pain: Study protocol of a randomised controlled trial
بواسطة: 2-s2.0-84954214739
منشور في: (2016)

An Exploratory Study of First Year Nursing Students Toward Their Perception on The First Experience of Clinical Practice – A Qualitative Study
بواسطة: 2-s2.0-85152142432
منشور في: (2022)

Cell Viability Assessment of PEDOT Conducting Polymer-Coated Microneedles for Skin Sampling
بواسطة: Mokhtar S.M.A.; Derrick-Roberts A.L.K.; Evans D.R.; Strudwick X.L.
منشور في: (2023)

Efficacy of yeast beta-glucan 1,3/1,6 supplementation on respiratory infection, fatigue, immune markers and gut health among moderate stress adults in Klang Valley of Malaysia: protocol for a randomised, double-blinded, placebo-controlled, parallel-group study
بواسطة: Mohamad Habibullah N.N.; Shahar S.; Ismail M.; Ibrahim N.; Kamaruddin M.Z.A.; Tang S.G.H.; Hamid M.F.A.; Ramasamy K.
منشور في: (2025)

Performance evaluation of online discussion
بواسطة: Jamaluddin M.R.; Hashim R.; Hanafiah M.H.M.; Mohd Zahari M.S.; Zulkifly M.I.
منشور في: (2010)

Natural Nail Colour based on Hylocereus polyrhizus and Curcuma longa Extracts; [Pewarna Kuku Semula Jadi berasaskan Ekstrak Hylocereus polyrhizus dan Curcuma longa]
بواسطة: Mazlan P.N.A.A.; Khalid R.M.; Rosli N.A.; Jamaluddin A.; Musa M.; Ola A.R.B.; Ramli S.
منشور في: (2025)

The inter-trial and inter-session reliability of Theia3D-derived markerless gait analysis in tight versus loose clothing
بواسطة: Augustine S.; Foster R.; Barton G.; Lake M.J.; Sharir R.; Robinson M.A.
منشور في: (2025)

Influence of coal ash on the concrete properties and its performance under sulphate and chloride conditions
بواسطة: Mangi S.A.; Wan Ibrahim M.H.; Jamaluddin N.; Arshad M.F.; Khahro S.H.; Putra Jaya R.
منشور في: (2021)

Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial
بواسطة: Bosch J.; Eikelboom J.W.; Connolly S.J.; Bruns N.C.; Lanius V.; Yuan F.; Misselwitz F.; Chen E.; Diaz R.; Alings M.; Lonn E.M.; Widimsky P.; Hori M.; Avezum A.; Piegas L.S.; Bhatt D.L.; Branch K.R.H.; Probstfield J.L.; Liang Y.; Liu L.; Zhu J.; Maggioni A.P.; Lopez-Jaramillo P.; O'Donnell M.; Fox K.A.A.; Kakkar A.; Parkhomenko A.N.; Ertl G.; Störk S.; Keltai K.; Keltai M.; Ryden L.; Dagenais G.R.; Pogosova N.; Dans A.L.; Lanas F.; Commerford P.J.; Torp-Pedersen C.; Guzik T.J.; Verhamme P.B.; Vinereanu D.; Kim J.-H.; Ha J.-W.; Tonkin A.M.; Varigos J.D.; Lewis B.S.; Felix C.; Yusoff K.; Steg P.G.; Aboyans V.; Metsarinne K.P.; Anand S.S.; Hart R.G.; Lamy A.; Moayyedi P.; Leong D.P.; Sharma M.; Yusuf S.
منشور في: (2017)

Population pharmacokinetics of caspofungin in critically ill patients receiving extracorporeal membrane oxygenation—an ASAP ECMO study
بواسطة: Abdul-Aziz M.H.; Diehl A.; Liu X.; Cheng V.; Corley A.; Gilder E.; Levkovich B.; McGuinness S.; Ordonez J.; Parke R.; Pellegrino V.; Wallis S.C.; Fraser J.F.; Shekar K.; Roberts J.A.
منشور في: (2025)

Novel Approaches in Primary Cardiovascular Disease Prevention: The HOPE-3 Trial Rationale, Design, and Participants' Baseline Characteristics
بواسطة: Lonn E.; Bosch J.; Pogue J.; Avezum A.; Chazova I.; Dans A.; Diaz R.; Fodor G.J.; Held C.; Jansky P.; Keltai M.; Keltai K.; Kunti K.; Kim J.-H.; Leiter L.; Lewis B.; Liu L.; Lopez-Jaramillo P.; Pais P.; Parkhomenko A.; Peters R.J.G.; Piegas L.S.; Reid C.M.; Sliwa K.; Toff W.D.; Varigos J.; Xavier D.; Yusoff K.; Zhu J.; Dagenais G.; Yusuf S.
منشور في: (2016)

Recycling of coal ash in concrete as a partial cementitious resource
بواسطة: Mangi S.A.; Ibrahim M.H.W.; Jamaluddin N.; Arshad M.F.; Mudjanarko S.W.
منشور في: (2019)

An international, stepped wedge, cluster-randomized trial investigating the 0/1-h algorithm in suspected acute coronary syndrome in Asia: the rational of the DROP-Asian ACS study
بواسطة: Inoue K.; Chieh J.T.W.; Yeh L.C.; Chiang S.-J.; Phrommintikul A.; Suwanasom P.; Kasim S.; Ahmad B.; Idrose A.M.; Salleh F.M.; Oyamada S.; Hirano Y.; Ouchi S.; Terakura M.; Yokoyama N.; Kozuma K.; Nanasato M.; Higuchi R.; Yumoto K.; Fukuzawa T.; Shimada I.; Giannitsis E.; Twerenbold R.; Minamino T.
منشور في: (2022)

Rationale and design of a cluster randomized trial of a multifaceted intervention in people with hypertension: The Heart Outcomes Prevention and Evaluation 4 (HOPE-4) Study
بواسطة: Schwalm J.-D.R.; McCready T.; Lamelas P.; Musa H.; Lopez-Jaramillo P.; Yusoff K.; McKee M.; Camacho P.A.; Lopez-Lopez J.; Majid F.; Thabane L.; Islam S.; Yusuf S.
منشور في: (2018)

Justice on Trial: How Artificial Intelligence is Reshaping Judicial Decision-Making
بواسطة: Andriati S.L.; Rizki I.K.; Malian A.N.B.M.
منشور في: (2024)

Rationale, Design and Baseline Characteristics of Participants in the Cardiovascular Outcomes for People Using Anticoagulation Strategies (COMPASS) Trial
بواسطة: 2-s2.0-85026258046
منشور في: (2017)

A randomized controlled trial to examine the effectiveness of the Dutch version of the Program for the Education and Enrichment of Relational Skills (PEERS®)
بواسطة: 2-s2.0-85128801887
منشور في: (2022)

Safety and efficacy of very low carbohydrate diet in patients with diabetic kidney disease—A randomized controlled trial
بواسطة: 2-s2.0-85117200198
منشور في: (2021)

Randomized controlled trial to compare the efficacy and safety of oral paricalcitol with oral calcitriol in dialysis patients with secondary hyperparathyroidism
بواسطة: 2-s2.0-84874492697
منشور في: (2013)

Effectiveness of a Dentist-based Anti-Smoking Intervention Among Malaysian Adolescents: A Randomized Controlled Field Trial
بواسطة: Radzi N.A.M.; Yusof Z.Y.M.
منشور في: (2025)

Safety of Proton Pump Inhibitors Based on a Large, Multi-Year, Randomized Trial of Patients Receiving Rivaroxaban or Aspirin
بواسطة: 2-s2.0-85070685740
منشور في: (2019)