Understanding the neuroprotective effect of tranexamic acid: an exploratory analysis of the CRASH-3 randomised trial

Background: The CRASH-3 trial hypothesised that timely tranexamic acid (TXA) treatment might reduce deaths from intracranial bleeding after traumatic brain injury (TBI). To explore the mechanism of action of TXA in TBI, we examined the timing of its effect on death. Methods: The CRASH-3 trial random...

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Bibliographic Details
Published in:Critical Care
Main Author: Brenner A.; Belli A.; Chaudhri R.; Coats T.; Frimley L.; Jamaluddin S.F.; Jooma R.; Mansukhani R.; Sandercock P.; Shakur-Still H.; Shokunbi T.; Roberts I.
Format: Article
Language:English
Published: BioMed Central Ltd 2020
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85095781531&doi=10.1186%2fs13054-020-03243-4&partnerID=40&md5=15c5815a3482e941f90ef01220ef9d47