4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation

QRコード

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation

Background: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...

書誌詳細
出版年:	BMC Chemistry
第一著者:	Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
フォーマット:	論文
言語:	English
出版事項:	BioMed Central Ltd 2019
オンライン･アクセス:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091148352&doi=10.1186%2fs13065-019-0533-7&partnerID=40&md5=dd621e6f2c49c8b9aca88b36cdd71944

類似資料

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors
著者:: 2-s2.0-85204404556
出版事項: (2025)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
著者:: 2-s2.0-85205956156
出版事項: (2025)

Antileshmanial activities of synthetic substituted 2-phenyl-4-[phenylmethylidene]-1,3-oxazol-5(4H)-ones
著者:: 2-s2.0-84953334043
出版事項: (2015)

Biology-oriented drug synthesis (BIODS): In vitro β-glucuronidase inhibitory and in silico studies on 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives
著者:: 2-s2.0-84998812010
出版事項: (2017)

Synthesis, spectral analysis and pharmacological study of N’-substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
著者:: 2-s2.0-85006043172
出版事項: (2016)

Innovative cholinergic scaffolds, synthesis, and characterization of substituted 1,2,4-triazole-3-ylthio-N-acetamides and their in silico studies: supplement against neurodegenerative disease
著者:: 2-s2.0-85146939634
出版事項: (2023)

Reverse pharmacophore mapping and molecular docking studies for discovery of GTPase HRas as promising drug target for bis-pyrimidine derivatives
著者:: Kumar S.; Singh J.; Narasimhan B.; Shah S.A.A.; Lim S.M.; Ramasamy K.; Mani V.
出版事項: (2018)

Synthesis Of Some N-(Un/Substituted-Phenyl)-2-(4-Phenyl-1-Piperazinyl)Acetamides as Possible Antibacterial and Anticancer Agents with Mild Cytotoxicity
著者:: 2-s2.0-85129470191
出版事項: (2022)

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
著者:: 2-s2.0-85057747839
出版事項: (2018)

Synthesis, pharmacological screening & computational analysis of some 2-(1H-Indol-3-yl)-N'-[(un)substituted phenylmethylidene] acetohydrazides & 2-(1H-Indol-3-yl)-N'-[(un)substituted benzoyl/2-Thienylcarbonyl]acetohydrazides
著者:: 2-s2.0-85021327600
出版事項: (2017)

Ethyl 4-[(2-hydroxyethyl)amino]-2-(4-methoxy-phenyl)-1-methyl-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylate
著者:: Abdul Rashid F.N.A.; Mohammat M.F.; Abdul Manan M.A.F.; Bakhtiar Afendy A.A.A.; Cordes D.B.; McKay A.P.
出版事項: (2024)

6-[(2E)-3,7-Dimethylocta-2,6-dien-1-yl]-5,7-dihydroxy-8-(2-methylbutanoyl) -4-phenyl-2H-chromen-2-one-6-[(2E)-3,7-dimethylocta-2,6-dien-1-yl]-5, 7-dihydroxy-8-(3-methylbutano-l)-4-phenyl-2H-chromen-2-one (1/1) from Mesua elegans
著者:: 2-s2.0-84860302949
出版事項: (2012)

N-(5-Methyl-1,3-Thiazol-2-yl)-2-{[5-((Un)Substituted- Phenyl)1,3,4-Oxadiazol-2-yl]Sulfanyl}acetamides. Unique Biheterocycles as Promising Therapeutic Agents
著者:: 2-s2.0-85061985685
出版事項: (2018)

Synthesis of promising antibacterial and antifungal agents: 2-[[(4-Chlorophenyl)sulfonyl](2,3-dihydro-1,4-benzodioxin-6-yl)amino]-N(un/substituted-phenyl)acetamides
著者:: 2-s2.0-85091220218
出版事項: (2020)

Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors
著者:: 2-s2.0-85091726412
出版事項: (2020)

Synthesis of novel N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[5-(un/substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as potent antibacterial agents
著者:: 2-s2.0-85129100563
出版事項: (2022)

Synthesis, biological evaluation, and molecular docking study of novel 1,2,4-substituted triazoles as inhibitors of alzheimer’s disease
著者:: 2-s2.0-85136203736
出版事項: (2022)

Synthesis, Kinetics and Computational Explorations of 4-Phenylpiperazine Bearing N-(Aryl)-3-substituted-benzamides as Auspicious Tyrosinase Inhibitors
著者:: 2-s2.0-85187520882
出版事項: (2024)

Synthesis, In Vitro, and In Silico Studies of N-(Substituted-Phenyl)-3-(4-Phenyl-1-Piperazinyl)propanamides as Potent Alkaline Phosphatase Inhibitors
著者:: 2-s2.0-85117566596
出版事項: (2021)

Synthesis, spectral analysis and biological evaluation of 2-{[(morpholin-4-yl)ethyl]thio}-5-phenyl/aryl-1,3,4-oxadiazole derivatives
著者:: 2-s2.0-85107334212
出版事項: (2021)

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
著者:: 2-s2.0-85076239103
出版事項: (2020)

Synthesis, in vitro and in silico studies of novel potent urease inhibitors: N-[4-({5-[(3-Un/substituted-anilino-3-oxopropyl)sulfanyl]-1,3,4-oxadiazol-2-yl}methyl)-1,3-thiazol-2-yl]benzamides
著者:: 2-s2.0-85048253105
出版事項: (2018)

Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4‑methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl) acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study
著者:: 2-s2.0-85073287972
出版事項: (2019)

Design, synthesis of triazole-based scaffolds, N-(substitutedphenyl)-2-(5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazol-3-ylthiol)acetamides: As potential anti-cholinesterase agents for neurodegenerative diseases
著者:: 2-s2.0-85160806262
出版事項: (2023)

Synthesis, Spectral Evaluation and in Silico Studies of S-Aralkylated 5-(4-methoxyphenyl)-4-phenyl-4H-1,2,4-triazole-3-thiols: As suitable Alzheimer's disease drug candidates
著者:: 2-s2.0-85121793476
出版事項: (2021)

Novel Bi-heterocycles as potent inhibitors of Urease and less cytotoxic agents: 3-({5-((2-amino-1,3-thiazol-4-yl)methyl)-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl) propanamides
著者:: 2-s2.0-85085346036
出版事項: (2020)

Synthesis of novel N-(1,3-thiazol-2-yl)benzamide clubbed oxadiazole scaffolds: Urease inhibition, Lipinski rule and molecular docking analyses
著者:: 2-s2.0-85054810473
出版事項: (2019)

Synthesis and biological evaluation of substituted benzohydrazide Schiff base adduct as potential cholinesterase inhibitors
著者:: 2-s2.0-85196391388
出版事項: (2024)

Characterization of zeolitic imidazole framework (ZIF-8) catalyst for potential biodiesel production from waste cooking oil (WCO)
著者:: Chai X.H.; Ng L.Y.; Ng C.Y.; Sim J.H.; Lim Y.P.; Liew J.Y.C.
出版事項: (2025)

Synthesis of new S-substituted derivatives of 5-[3-(1H-indol-3-yl) propyl]-1, 3, 4-oxadiazol-2-ylhydrosulfide as suitable antibacterial and anticancer agents with moderate cytotoxicity
著者:: 2-s2.0-85077920909
出版事項: (2019)

Synthesis and in silico study of 2-furyl(4-{4-[(substituted)sulfonyl]benzyl}-1-piperazinyl)methanone derivatives as suitable therapeutic agents
著者:: Hussain G.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-ul-Ain; Ahmad I.; Malik R.; Lodhi M.A.; Khan F.A.; Shahid M.; Fatima H.
出版事項: (2017)

Synthesis of some N-sulfonated derivatives of 1-[(E)-3-phenyl-2-propenyl]piperazine as suitable antibacterial agents
著者:: 2-s2.0-85090169024
出版事項: (2020)

Effects of crystallite size on the kinetics and mechanism of NiO reduction with H2
著者:: 2-s2.0-80055046402
出版事項: (2011)

Design of potent tyrosinase inhibiting N-arylated-4-yl-benzamides bearing 2-aminothiazole-triazole bi-heterocycles: mechanistic insight through enzyme inhibition, kinetics and computational studies
著者:: 2-s2.0-85194053288
出版事項: (2024)

Novel indole based hybrid oxadiazole scaffolds with: N -(substituted-phenyl)butanamides: Synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors
著者:: 2-s2.0-85050591556
出版事項: (2018)

Mixed matrix membranes incorporated with reduced graphene oxide (rGO) and zeolitic imidazole framework-8 (ZIF-8) nanofillers for gas separation
著者:: 2-s2.0-85058095048
出版事項: (2019)

Synthesis and β-glucuronidase inhibitory activity of 2-arylquinazolin-4(3H)-ones
著者:: 2-s2.0-84901927895
出版事項: (2014)

Synthesis and structure-activity relationship of 1-[(E)-3-phenyl-2-propenyl] piperazine derivatives as suitable antibacterial agents with mild hemolysis
著者:: 2-s2.0-85105482274
出版事項: (2019)

Synthesis and evaluation of novel 1, 2, 4-substituted triazoles for urease and anti-proliferative activity
著者:: 2-s2.0-85124607308
出版事項: (2022)

Synergetic effect of bismuth vanadate over copolymerized carbon nitride composites for highly efficient photocatalytic H2 and O2 generation
著者:: 2-s2.0-85134654990
出版事項: (2022)