4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation
Background: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...
| Published in: | BMC Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
BioMed Central Ltd
2019
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091148352&doi=10.1186%2fs13065-019-0533-7&partnerID=40&md5=dd621e6f2c49c8b9aca88b36cdd71944 |