Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches

In the current research work, different N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl}butanamides have been synthesized according to the protocol described in scheme 1. The synthesis was initiated by reacting various substituted anilines (1a-e) with 4-chlorobutanoyl chloride (...

Full description

Bibliographic Details
Published in:Bioorganic Chemistry
Main Author: Raza H.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Abbas Q.; Hong H.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Format: Article
Language:English
Published: Academic Press Inc. 2020
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85076239103&doi=10.1016%2fj.bioorg.2019.103445&partnerID=40&md5=24bac606e09b402de93524e55f2ab786