The Effects of Different Solubilizing Agents on the Transport and Pharmacokinetic Profiles of Indomethacin: in vitro and in vivo Approach

QR Code

The Effects of Different Solubilizing Agents on the Transport and Pharmacokinetic Profiles of Indomethacin: in vitro and in vivo Approach

The poor water solubility of new chemical entities (NCEs) discovered in pharmaceutical screening programs hampers their development and limits effective treatment delivery. Solubilizing agents offer a direct approach to increase solubility and oral bioavailability. This study employed indomethacin a...

Full description

Bibliographic Details
Published in:	SAINS MALAYSIANA
Main Authors:	Zainuddin, Siti aisyah; Ab Hamid, Abdul latip; Rafandi, Aqila iman; Mohamad, Mashani; Hamid, Khuriah abdul; Khalid, Syed haroon
Format:	Article
Language:	English
Published:	UNIV KEBANGSAAN MALAYSIA, FAC SCIENCE & TECHNOLOGY 2024
Subjects:	Science & Technology - Other Topics
Online Access:	https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-recordWOS:001367374600017

Similar Items

The Effects of Different Solubilizing Agents on the Transport and Pharmacokinetic Profiles of Indomethacin: in vitro and in vivo Approach; [Kesan Agen Pelarut Berbeza Terhadap Profil Pengangkutan dan Farmakokinetik Indometasin: Pendekatan in vitro dan in vivo]
by: Zainuddin S.A.; Hamid A.L.A.B.; Rafandi A.I.; Mohamad M.; Hamid K.A.; Khalid S.H.
Published: (2024)

The effect of Wellsolve, a novel solubilizing agent, on the intestinal barrier function and intestinal absorption of griseofulvin in rats
by: Hamid K.A.; Lin Y.; Gao Y.; Katsumi H.; Sakane T.; Yamamoto A.
Published: (2009)

Polyethylene glycol-mediated functionalization of nanodelivery systems for improving their pharmacokinetic profile and anticancer efficacy
by: Al-Shadidi J.R.M.H.; Hussain Z.; Ahmed I.S.; Rawas-Qalaji M.; Thu H.E.; Khan S.
Published: (2024)

New halogenated chalcones as potential anti-inflammatory agents: A comprehensive In-Silico, In-Vitro, and In-Vivo study with ADME profiling
by: Iqtadar R.; Naz A.; Shah S.A.A.; Ali S.; Abdullah S.
Published: (2025)

Enhanced Rice (Oryza sativa L.) Plant Growth and Nutrient Contents During The Vegetative Stage Through Zinc Solubilizing Bacterial Bead Inoculation
by: Ramly I.S.; Othman N.M.I.; Shamsuddin A.S.; Zuan A.T.K.; Zakaria N.H.; Abdul Majid F.A.; Hamid N.A.
Published: (2024)

BIOANALYTICAL OF UPLC METHOD DEVELOPMENT AND VALIDATION OF XANTHORRIZOL AND ITS APPLICATION TO PHARMACOKINETIC STUDY
by: Noviza D.; Julianto T.; Majeed A.B.A.; Hamid K.A.
Published: (2024)

Therapeutic potentials of iridoids derived from Rubiaceae against in vitro and in vivo inflammation: A scoping review
by: Jaafar, et al.
Published: (2024)

Effects of pure and fake honey on glucose and lipid profile in vitro and in vivo study
by: Zulkifli M.F.; Samat S.; Azam N.S.M.; Enchang F.K.; Razak A.A.; Hussein F.N.; Ismail W.I.W.
Published: (2020)

Goniothalamin and Its Analogues as Potential Inhibitors of Plasmodium falciparum Lactate Dehydrogenase Enzyme: Molecular Docking, Molecular Dynamics Simulation Studies, and Pharmacokinetics Analysis
by: Ideris S.; Imran S.; Latip N.A.; Osman C.P.
Published: (2024)

Protective effects of (1-(4-hydroxy-phenyl)-3-m-tolyl-propenone chalcone in indomethacin-induced gastric erosive damage in rats
by: Dhiyaaldeen S.M.; Amin Z.A.; Darvish P.H.; Mustafa I.F.; Jamil M.M.; Rouhollahi E.; Abdulla M.A.
Published: (2014)

The Design of the New Fractional Block Method in the Solution of the Three-Compartment Pharmacokinetics Model
by: Noor, et al.
Published: (2024)

The Design of the New Fractional Block Method in the Solution of the Three-Compartment Pharmacokinetics Model
by: Noor N.M.; Yatim S.A.M.; Zawawi I.S.M.
Published: (2024)

COMPARATIVE EFFECT OF RHIZOSPHERIC AND ENDOPHYTIC BACTERIA ON TCP AND CaCO3 SOLUBILIZATION AND GROWTH PROMOTION OF WHEAT (TRITICUM AESTIVUM L.)
by: Javed S.; Mazhar M.W.; Yusof N.Y.; Rehan M.B.M.; Hanaphi R.M.; Ahmad N.S.-H.N.; Yaakob A.S.; Harun H.C.; Aziz T.; Alharbi M.; Alasmari A.F.
Published: (2024)

Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models
by: Sadikan M.Z.; Abdul Nasir N.A.; Lambuk L.; Mohamud R.; Reshidan N.H.; Low E.; Singar S.A.; Mohmad Sabere A.S.; Iezhitsa I.; Agarwal R.
Published: (2023)

Cubosomes hydrogel containing silver based organometallic compounds for enhanced wound healing of burns: In vitro and in vivo studies
by: Farooq, et al.
Published: (2024)

Dexibuprofen loaded into nanoemulsion based gel for topical application - In vitro characterization and in vivo anti-inflammatory evaluation
by: Munir, et al.
Published: (2025)

“Role of Human Factor for the Implementation of the “Vision Zero” Concept in Railway Transport: An Overview”
by: Muhammed Nor M.A.; Jaganathapillai T.; Yusop A.F.; Hamidi M.A.; Omar M.N.; Abdul Hamid N.A.; Wan Mohamed W.M.
Published: (2024)

Molecular Docking and ADME Profiles of Hyrtiosulawesine Derivatives Targeting pfLDH: Exploring Potential as Antimalarial Agents
by: Zulkifli S.Z.; Abdul Aziz A.A.; Saaidin A.S.; Hamzah N.; Pungot N.H.
Published: (2024)

Faculty of Pharmacy Shares Experience Transitioning from Traditional Lab Practicals to Objective Structured Pharmacy Assessment (OSPA)
by: Ramli, et al.
Published: (2024)

New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects
by: Ei Thu H.; Hussain Z.; Shuid A.N.
Published: (2018)

An Update on Impacts of Epigallocatechin Gallate Co-Administration in Modulating Pharmacokinetics of Statins, Calcium Channel Blockers, and Beta-blockers
by: Siew-Keah L.; Jie T.H.; Ang-Lim C.; Bin L.K.; Yik-Ling C.
Published: (2023)

Cell membrane cloaked nanomedicines for bio-imaging and immunotherapy of cancer: Improved pharmacokinetics, cell internalization and anticancer efficacy
by: Hussain Z.; Rahim M.A.; Jan N.; Shah H.; Rawas-Qalaji M.; Khan S.; Sohail M.; Thu H.E.; Ramli N.A.; Sarfraz R.M.; Abourehab M.A.S.
Published: (2021)

Generation of a novel ex-vivo model to study re-endothelialization
by: Azman S.S.; Yazid M.D.; Abdul Ghani N.A.; Raja Sabudin R.Z.A.; Abdul Rahman M.R.; Sulaiman N.
Published: (2023)

Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
by: Tahlan S.; Kumar S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Pathania R.; Narasimhan B.
Published: (2019)

In vitro and in silico assessment of bioactivity properties and pharmacokinetic studies of new 3,5-disubstituted-1,2,4-triazoles
by: Amjad H.; Abbasi M.A.; Siddiqui S.Z.; Iqbal J.; Rasool S.; Ashraf M.; Hussain S.; Shah S.A.A.; Imran S.; Shahid M.; Rasool A.; Rehman M.T.; Rehman A.U.
Published: (2023)

Ischemic brain treated with 6-gingerol loaded mucoadhesive nanoemulsion via intranasal delivery and their comparative pharmacokinetic effect in brain
by: Ahmad N.; Ahmad R.; Amir M.; Alam M.A.; Almakhamel M.Z.; Ali A.; Ahmad A.; Ashraf K.
Published: (2021)

Tourism and Public Transport
by: Azman I.; Jean L.X.; Hall C.M.; Prayag G.
Published: (2024)

Development of universal wheelchair transporter
by: Zulkepli N.F.A.; Khusairi S.; Shaari M.S.B.; Khusaini N.S.; Aziz N.; Sainan K.I.; Mohamed Z.
Published: (2018)

Exploring dynamic biomedical algorithm of Eurycoma longifolia Jack and its bioactive phytochemicals: A review of pharmacokinetic and pharmacodynamic implications and future prospects
by: Thu H.; Hussain Z.; Mohamed I.; Shuid A.
Published: (2018)

Taking flight: Exploring the relationship between air transport and Malaysian economic growth
by: Raihan, et al.
Published: (2024)

Methods for improving the in-cylinder airflow characteristics for sustainable transportation using fuels with higher viscosity: A review
by: Hamid M.F.; Idroas M.Y.; Mazlan M.; Sa'ad S.; Teoh Y.H.; Che Mat S.; Miskam M.A.; Abdullah M.K.
Published: (2022)

Lactobacilli-fermented cow's milk attenuated lipopolysaccharide-induced neuroinflammation and memory impairment in vitro and in vivo
by: Musa N.H.; Mani V.; Lim S.M.; Vidyadaran S.; Abdul Majeed A.B.; Ramasamy K.
Published: (2017)

Corrigendum to: The Role of Transport in Reverse Distribution Chains (The Open Transportation Journal", 2021 Dec 20; 15: 256)
by: Shaharudin M.O.
Published: (2022)

Alginate encapsulation of Trichoderma harzianum against brown spot disease on rice (Oryzae sativa) in vivo assays
by: Mohd Anuar I.S.; Ku Sulong K.A.; Abdul Ghani H.; Wahab M.Z.
Published: (2020)

The Belief-Desire-Intention Architecture of Sincere Software Agent Environment
by: Jaafar N.H.; Ahmad A.; Ahmad M.S.; Hamid N.H.A.
Published: (2021)

Mean Solar Quiet Profiling of Geomagnetic Field H-Component for Langkawi Observatory in Solar Cycle-24
by: Hashim M.H.; Jusoh M.H.; Abdul Hamid N.S.; Khirul Ashar N.D.; Mohd Radzi Z.; Yoshikawa A.
Published: (2024)

Therapeutic potentials of iridoids derived from Rubiaceae against in vitro and in vivo inflammation: A scoping review
by: Jaafar A.; Zulkipli M.A.; Mohd Hatta F.H.; Jahidin A.H.; Abdul Nasir N.A.; Hazizul Hasan M.
Published: (2024)

Towards Sustainable Public Transportation Cost in Malaysia
by: Ab Majid R.; Said R.; Sahray K.; Mustafar S.; Kaspin M.
Published: (2022)

Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study
by: Muhtadi; Haryoto; Azizah T.; Suhendi A.; Yen K.H.
Published: (2015)

Insights into water-lubricated transport of heavy and extra-heavy oils: Application of CFD, RSM, and metaheuristic optimized machine learning models
by: Alsehli, et al.
Published: (2024)