Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents

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Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents

The current study was aimed to synthesize piperazine-based bis-Schiff base derivatives (1-15) and were also screened in vitro for their inhibition against urease enzyme under the positive control of thiourea drug (IC50 value of 36.40 +/- 2.35 mu M). Among the tested analogs, the maximum potency was...

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Bibliographic Details
Published in:	CHEMISTRYSELECT
Main Authors:	Masood, Najat; Hussain, Rafaqat; Khan, Shoaib; Rahim, Fazal; Mumtaz, Sundas; Taha, Muhammad; Abid, Obaid Ur Rahman; Iqbal, Tayyiaba; Shah, Syed Adnan Ali; Al Wesabi, Esam Omar; Magam, Seami M.
Format:	Article
Language:	English
Published:	WILEY-V C H VERLAG GMBH 2024
Subjects:	Chemistry
Online Access:	https://www-webofscience-com.uitm.idm.oclc.org/wos/woscc/full-record/WOS:001292248200001

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