In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review
This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro...
| 發表在: | AAPS PharmSciTech |
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| 主要作者: | |
| 格式: | Review |
| 語言: | English |
| 出版: |
Springer New York LLC
2019
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| 在線閱讀: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064531332&doi=10.1208%2fs12249-019-1362-7&partnerID=40&md5=670898e9a34f95aea122bb4030a8b478 |
| id |
Sheshala R.; Anuar N.K.; Abu Samah N.H.; Wong T.W. |
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| spelling |
Sheshala R.; Anuar N.K.; Abu Samah N.H.; Wong T.W. 2-s2.0-85064531332 In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review 2019 AAPS PharmSciTech 20 5 10.1208/s12249-019-1362-7 https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064531332&doi=10.1208%2fs12249-019-1362-7&partnerID=40&md5=670898e9a34f95aea122bb4030a8b478 This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro dissolution/permeation methods are available for skin product testing with no specific application to nanocarriers. Researchers are largely utilizing the in-house dissolution/permeation testing methods of nanocarriers. These drug release and permeation methods are pending to be standardized. Their biorelevance with reference to in vivo plasma concentration–time profiles requires further exploration to enable translation of in vitro data for in vivo or clinical performance prediction. © 2019, American Association of Pharmaceutical Scientists. Springer New York LLC 15309932 English Review |
| author |
2-s2.0-85064531332 |
| spellingShingle |
2-s2.0-85064531332 In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review |
| author_facet |
2-s2.0-85064531332 |
| author_sort |
2-s2.0-85064531332 |
| title |
In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review |
| title_short |
In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review |
| title_full |
In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review |
| title_fullStr |
In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review |
| title_full_unstemmed |
In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review |
| title_sort |
In Vitro Drug Dissolution/Permeation Testing of Nanocarriers for Skin Application: a Comprehensive Review |
| publishDate |
2019 |
| container_title |
AAPS PharmSciTech |
| container_volume |
20 |
| container_issue |
5 |
| doi_str_mv |
10.1208/s12249-019-1362-7 |
| url |
https://www.scopus.com/inward/record.uri?eid=2-s2.0-85064531332&doi=10.1208%2fs12249-019-1362-7&partnerID=40&md5=670898e9a34f95aea122bb4030a8b478 |
| description |
This review highlights in vitro drug dissolution/permeation methods available for topical and transdermal nanocarriers that have been designed to modulate the propensity of drug release, drug penetration into skin, and permeation into systemic circulation. Presently, a few of USFDA-approved in vitro dissolution/permeation methods are available for skin product testing with no specific application to nanocarriers. Researchers are largely utilizing the in-house dissolution/permeation testing methods of nanocarriers. These drug release and permeation methods are pending to be standardized. Their biorelevance with reference to in vivo plasma concentration–time profiles requires further exploration to enable translation of in vitro data for in vivo or clinical performance prediction. © 2019, American Association of Pharmaceutical Scientists. |
| publisher |
Springer New York LLC |
| issn |
15309932 |
| language |
English |
| format |
Review |
| accesstype |
|
| record_format |
scopus |
| collection |
Scopus |
| _version_ |
1828987875412148224 |