Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents

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Synthesis, In Vitro Enzymatic Inhibition, and Molecular Modeling of Novel Piperazine-Based Bis-Schiff Base Derivatives as Promising Anti-urease Agents

The current study was aimed to synthesize piperazine-based bis-Schiff base derivatives (1–15) and were also screened in vitro for their inhibition against urease enzyme under the positive control of thiourea drug (IC50 value of 36.40±2.35 μM). Among the tested analogs, the maximum potency was shown...

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Bibliographic Details
Published in:	ChemistrySelect
Main Author:	Masood N.; Hussain R.; Khan S.; Rahim F.; Mumtaz S.; Taha M.; Ur Rahman Abid O.; Iqbal T.; Adnan Ali Shah S.; Omar Al Wesabi E.; Magam S.M.
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201207394&doi=10.1002%2fslct.202401106&partnerID=40&md5=64ac55dbff51d9106a24c7f2fdcf3e69

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