Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells

QR Code

Role of TGF-β1/SMADs signalling pathway in resveratrol-induced reduction of extracellular matrix deposition by dexamethasone-treated human trabecular meshwork cells

Deposition of extracellular matrix (ECM) in the trabecular meshwork (TM) increases aqueous humour outflow resistance leading to elevation of intraocular pressure (IOP) in primary open-angle glaucoma, which remains the only modifiable risk factor. Resveratrol has been shown to counteract the steroid-...

Full description

Bibliographic Details
Published in:	Korean Journal of Physiology and Pharmacology
Main Author:	Bakar A.S.A.; Razali N.; Agarwal R.; Iezhitsa I.; Perfilev M.A.; Vassiliev P.M.
Format:	Article
Language:	English
Published:	Korean Physiological Soc. and Korean Soc. of Pharmacology 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85198983678&doi=10.4196%2fkjpp.2024.28.4.345&partnerID=40&md5=69978ed7e604b9f53154f00092f8906f

Similar Items

IOP lowering effect of topical trans-resveratrol involves adenosine receptors and TGF-β2 signaling pathways
by: Razali N.; Agarwal R.; Agarwal P.; Froemming G.R.A.; Tripathy M.; Ismail N.M.
Published: (2018)

Connective tissue growth factor: Role in trabecular meshwork remodeling and intraocular pressure lowering
by: Hassan M.D.S.; Razali N.; Abu Bakar A.S.; Abu Hanipah N.F.; Agarwal R.
Published: (2023)

Intraocular pressure-lowering effects of imidazo[1,2-a]- and pyrimido[1,2-a]benzimidazole compounds in rats with dexamethasone-induced ocular hypertension
by: Marcus A.J.; Iezhitsa I.; Agarwal R.; Vassiliev P.; Spasov A.; Zhukovskaya O.; Anisimova V.; Ismail N.M.
Published: (2019)

Baeckea frutescens L. Promotes wound healing by upregulating expression of TGF-β, IL-1 β, VEGF and MMP-2
by: Safwan Kamarazaman I.; Sui Kiong L.; Nik Hasan M.K.; Basherudin N.; Mohd Kasim N.A.; Ali A.A.; Ramli S.; Maniam S.; Johari James R.; Rojsitthisak P.; Halim H.
Published: (2024)

Baeckea frutescens L. Promotes wound healing by upregulating expression of TGF-β, IL-1 β, VEGF and MMP-2
by: Kamarazaman, et al.
Published: (2024)

Neuroprotection by Trans-Resveratrol in Rats with Intracerebral Hemorrhage: Insights into the Role of Adenosine A1 Receptors
by: Abd. Aziz N.A.W.; Iezhitsa I.; Agarwal R.; Bakar N.S.; Abd. Latiff A.; Ismail N.M.
Published: (2022)

Unlocking the Potential of Extracellular Vesicles as the Next Generation Therapy: Challenges and Opportunities
by: Che Shaffi S.; Hairuddin O.N.; Mansor S.F.; Syafiq T.M.F.; Yahaya B.H.
Published: (2024)

Trabecular bone microstructure parameters as predictors for chronological age: a systematic review
by: Tabassum A.; Singh M.K.C.; Ibrahim N.; Sanjeevan V.; Yusof M.Y.P.M.
Published: (2024)

Effect of reconstruction parameters on cone beam CT trabecular bone microstructure quantification in sheep
by: Muhammad A.M.A.; Ibrahim N.; Ahmad R.; Asif M.K.; Radzi Z.; Zaini Z.M.; Razak H.R.A.
Published: (2020)

Extraction of Extracellular Membrane Vesicles (EMV) from Streptococcus pneumoniae using Ultracentrifugation, Ultrafiltration and Iodixanol Gradient Fractionation
by: Anuar N.F.Z.; Desa M.N.M.; Hussaini J.; Wong E.H.; Mariappan V.; Vellasamy K.M.; Navindra Kumari P.
Published: (2023)

Designing the Right Games Strategy: Evidence-Based Technology of Teaching Games for Understanding (TGfU) Model
by: Abdul Ghani D.Z.; Zainuddin Z.A.; Mohd Hashim A.H.; Ibrahim H.; Mohamed A.M.D.
Published: (2024)

Effect of 3D and 2D cell culture systems on trophoblast extracellular vesicle physico-chemical characteristics and potency
by: Khan N.L.A.; Muhandiram S.; Dissanayake K.; Godakumara K.; Midekessa G.; Andronowska A.; Heath P.R.; Kodithuwakku S.; Hart A.R.; Fazeli A.
Published: (2024)

Resveratrol Oligomers from the Twigs of Neobalanocarpus heimii ( King) PS Ashton (Dipterocarpaceae)
by: Zakaria, et al.
Published: (2023)

Comparative Dose- and Time-Dependent Manner of Resveratrol on Human Epithelial Cell Types
by: Effendy W.N.F.W.E.; S. M. N. Mydin R.B.; Shanker K.; Ng K.Y.; Sundaraju P.; Gunasagaran S.; Ahmad Sopian S.F.; Mohd Gazzali A.
Published: (2022)

Cytotoxic and Antibacterial Properties of Resveratrol Oligomers from the Stem Bark of Dryobalanops rappa
by: Wibowo A.; Ahmat N.; Biau F.J.; Loh J.S.; Hamzah A.S.
Published: (2022)

Quantifications of Mandibular Trabecular Bone Microstructure Using Cone Beam Computed Tomography for Age Estimation: A Preliminary Study
by: Tabassum A.; Chainchel Singh M.K.; Ibrahim N.; Ramanarayanan S.; Mohd Yusof M.Y.P.
Published: (2022)

Intraocular pressure lowering effect and structure-activity relationship of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats: Insight on possible link with hypotensive activity
by: Marcus A.J.; Iezhitsa I.; Agarwal R.; Vassiliev P.; Spasov A.; Zhukovskaya O.; Anisimova V.; Johari B.; Mohd Ismail N.
Published: (2018)

Chemotaxonomic Relationship of Oligomer Resveratrol in Three Malaysian Dipterocarpus Species from the Taxonomic Tribe of Dipterocarpaceae
by: Nawi L.; Zain W.Z.W.M.; Ahmat N.; Osman C.P.; Takaya Y.; Kamarozaman A.S.; Adnan N.; Azahar S.Z.
Published: (2024)

Regio- and stereoselective biomimetic synthesis of oligostilbenoid dimers from resveratrol analogues: Influence of the solvent, oxidant, and substitution
by: Velu S.S.; Buniyamin I.; Ching L.K.; Feroz F.; Noorbatcha I.; Gee L.C.; Awang K.; Wahab I.Abd.; Weber J.-F.F.
Published: (2008)

Role of adenosine receptors in resveratrol-induced intraocular pressure lowering in rats with steroid-induced ocular hypertension
by: Razali N.; Agarwal R.; Agarwal P.; Kumar S.; Tripathy M.; Vasudevan S.; Crowston J.G.; Ismail N.M.
Published: (2015)

Modulation of LOX and COX pathways via inhibition of amyloidogenesis contributes to mitoprotection against β-amyloid oligomer-induced toxicity in an animal model of Alzheimer's disease in rats
by: Kalra J.; Kumar P.; Majeed A.B.A.; Prakash A.
Published: (2016)

Centella asiatica protects D-galactose/AlCl3 mediated alzheimer’s disease-like rats via PP2A/GSK-3β signaling pathway in their hippocampus
by: Chiroma S.M.; Baharuldin M.T.H.; Taib C.N.M.; Amom Z.; Jagadeesan S.; Adenan M.I.; Mahdi O.; Moklas M.A.M.
Published: (2019)

The revolution of matrix converter: moving towards decarbonization technology
by: Baharom R.
Published: (2023)

Classification of risk of voltage collapse using risk matrix
by: Aminudin N.; Ramli N.M.; Marsadek M.; Rahman T.K.A.
Published: (2016)

Asymptomatic neurotoxicity of amyloid β-peptides (Aβ1-42 and aβ25-35 ) on mouse embryonic stem cell-derived neural cells
by: Mansor N.I.; Ntimi C.M.; Abdul-Aziz N.M.; Ling K.-H.; Adam A.; Rosli R.; Hassan Z.; Nordin N.
Published: (2021)

Solid-state transformer (S2T) of single phase matrix converter
by: Zainuddin Z.; Baharom R.; Yassin I.M.; Muhammad K.S.
Published: (2018)

Development of Polyvinyl Alcohol/Chitosan Nanoparticles Mixed-Matrix Membrane
by: Fauzi B.; Zainal Abidin Z.U.; Mohamad Roslan R.; Mohd Ismail N.I.; Fauzi R.; Muhamad A.; Mohd Noor S.F.
Published: (2024)

Construction of tvet students' career profile pathways
by: Mohd Nor A.R.; Rasul M.S.; Amat S.
Published: (2021)

Sustainable manufacturing 4.0-pathways and practices
by: Gholami H.; Abu F.; Lee J.K.Y.; Karganroudi S.S.; Sharif S.
Published: (2021)

Matrix Metalloproteinases in Chemoresistance: Regulatory Roles, Molecular Interactions, and Potential Inhibitors
by: Tune B.X.J.; Sim M.S.; Poh C.L.; Guad R.M.; Woon C.K.; Hazarika I.; Das A.; Gopinath S.C.B.; Rajan M.; Sekar M.; Subramaniyan V.; Fuloria N.K.; Fuloria S.; Batumalaie K.; Wu Y.S.
Published: (2022)

Development of boost inverter using single phase matrix converter topology
by: Mohd Zin M.F.; Baharom R.; Mohd Yassin I.
Published: (2018)

The Lefkovitch Matrix of Aedes Aegypti with Rainfall Dependent Model for Eggs Hatching
by: Tokachil M.N.; Yahya A.
Published: (2019)

Compressive and wear resistance of alumina reinforced Fe-Cr matrix composites
by: Shamsuddin S.; Shamsul B.J.; Hussain Z.; Zainal A.A.
Published: (2013)

Zero-One Matrix on Tudung Saji Pattern via Image Processing
by: Ramli M.; Ahmad M.A.; Mohamad M.S.
Published: (2025)

Novel Weakness Multivariate Quadratic Structures Detected within Macaulay Matrix
by: Abdullah K.; Ariffin M.R.K.; Abdul Jamal N.A.S.
Published: (2025)

Pectin matrix as oral drug delivery vehicle for colon cancer treatment
by: Wong T.W.; Colombo G.; Sonvico F.
Published: (2011)

Inside Microfinance Matrix: Microfinance Institutions’ Characteristics and Women Credit Access
by: Jasmi Z.S.; Hassan N.
Published: (2024)

The pathway toward sustainable and resilient infrastructure development in Malaysia
by: Mustaffa N.K.; Shahrudin N.S.N.; Mustaffa A.
Published: (2023)

Empowering Career Pathways for Asnaf Faqir (Poor People)
by: Akbar A.A.; Rameli M.F.P.; Nor A.R.M.; Rohana N.A.M.
Published: (2024)

Targeting signaling pathways with andrographolide in cancer therapy (Review)
by: Shaharudin N.S.; Singh G.K.S.; Kek T.L.; Sultan S.
Published: (2024)