Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights

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Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights

Aim: Synthesis of novel bis-Schiff bases having potent inhibitory activity against phosphodiesterase (PDE-1 and -3) enzymes, potentially offering therapeutic implications for various conditions. Methods:Bis-Schiff bases were synthesized by refluxing 2,4-dihydroxyacetophenone with hydrazine hydrate,...

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Bibliographic Details
Published in:	Future Medicinal Chemistry
Main Author:	Alam A.; Gul S.; Zainab; Khan M.; Elhenawy A.A.; Islam M.S.; Ali M.; Ali Shah S.A.; Latif A.; Ahmad M.
Format:	Article
Language:	English
Published:	Taylor and Francis Ltd. 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193757947&doi=10.1080%2f17568919.2024.2342707&partnerID=40&md5=a0ba825c3df785e48af67556df92ecde

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