Synthesis of 2,4-dihydroxyacetophenone derivatives as potent PDE-1 and -3 inhibitors: in vitro and in silico insights
Aim: Synthesis of novel bis-Schiff bases having potent inhibitory activity against phosphodiesterase (PDE-1 and -3) enzymes, potentially offering therapeutic implications for various conditions. Methods:Bis-Schiff bases were synthesized by refluxing 2,4-dihydroxyacetophenone with hydrazine hydrate,...
Published in: | Future Medicinal Chemistry |
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Main Author: | |
Format: | Article |
Language: | English |
Published: |
Taylor and Francis Ltd.
2024
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Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85193757947&doi=10.1080%2f17568919.2024.2342707&partnerID=40&md5=a0ba825c3df785e48af67556df92ecde |