Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach

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Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach

This research is based on the synthesis, characterization and in vitro α-glucosidase inhibitory activity of fourteen amides (2 a–2 n) of flurbiprofen drug. Seven compounds in the series displayed potent inhibitory activity having IC50 values (IC50=5.67±0.89 μM) to (IC50=17.87±2.39 μM) in comparison...

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Bibliographic Details
Published in:	ChemistrySelect
Main Author:	Alam A.; Zainab; Elhenawy A.A.; Ur Rehman N.; Shahidul Islam M.; Dahlous K.A.; Talab F.; Shah S.A.A.; Ali M.; Ahmad M.
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191891273&doi=10.1002%2fslct.202401296&partnerID=40&md5=ae0c3acea5a089c81db3f5131dce9fdd

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