Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach

Synthesis of Flurbiprofen Based Amide Derivatives as Potential Leads for Diabetic Management: In Vitro α-glucosidase Inhibition, Molecular Docking and DFT Simulation Approach

This research is based on the synthesis, characterization and in vitro α-glucosidase inhibitory activity of fourteen amides (2 a–2 n) of flurbiprofen drug. Seven compounds in the series displayed potent inhibitory activity having IC50 values (IC50=5.67±0.89 μM) to (IC50=17.87±2.39 μM) in comparison...

Full description

Bibliographic Details
Published in:ChemistrySelect
Main Author: Alam A.; Zainab; Elhenawy A.A.; Ur Rehman N.; Shahidul Islam M.; Dahlous K.A.; Talab F.; Shah S.A.A.; Ali M.; Ahmad M.
Format: Article
Language:English
Published: John Wiley and Sons Inc 2024
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191891273&doi=10.1002%2fslct.202401296&partnerID=40&md5=ae0c3acea5a089c81db3f5131dce9fdd

Internet

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85191891273&doi=10.1002%2fslct.202401296&partnerID=40&md5=ae0c3acea5a089c81db3f5131dce9fdd

Similar Items