Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors

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Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors

Urease, a nickel-dependent enzyme found in various life forms, catalyzes urea breakdown, concluding nitrogen metabolism by generating ammonia and carbamate. This process causes a rise in pH, supports the survival of pathogens, and can lead to infections such as gastric disorders like ulcers and canc...

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Bibliographic Details
Published in:	Frontiers in Chemistry
Main Author:	Akash M.; Zaib S.; Ahmad M.; Sultan S.; Al-Hussain S.A.
Format:	Article
Language:	English
Published:	Frontiers Media SA 2024
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188661030&doi=10.3389%2ffchem.2024.1371377&partnerID=40&md5=4db47f04631f1ffeacfc77d2a3891b95

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