Synthesis and biological evaluation of pyridylpiperazine hybrid derivatives as urease inhibitors
Urease, a nickel-dependent enzyme found in various life forms, catalyzes urea breakdown, concluding nitrogen metabolism by generating ammonia and carbamate. This process causes a rise in pH, supports the survival of pathogens, and can lead to infections such as gastric disorders like ulcers and canc...
| Published in: | Frontiers in Chemistry |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media SA
2024
|
| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85188661030&doi=10.3389%2ffchem.2024.1371377&partnerID=40&md5=4db47f04631f1ffeacfc77d2a3891b95 |