Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models

QR Code

Diabetic retinopathy: a comprehensive update on in vivo, in vitro and ex vivo experimental models

Diabetic retinopathy (DR), one of the leading causes of visual impairment and blindness worldwide, is one of the major microvascular complications in diabetes mellitus (DM). Globally, DR prevalence among DM patients is 25%, and 6% have vision-threatening problems among them. With the higher incidenc...

Full description

Bibliographic Details
Published in:	BMC Ophthalmology
Main Author:	Sadikan M.Z.; Abdul Nasir N.A.; Lambuk L.; Mohamud R.; Reshidan N.H.; Low E.; Singar S.A.; Mohmad Sabere A.S.; Iezhitsa I.; Agarwal R.
Format:	Review
Language:	English
Published:	BioMed Central Ltd 2023
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85174484154&doi=10.1186%2fs12886-023-03155-1&partnerID=40&md5=8cf97fff89376233dd08daf891a00a8f

Similar Items

Development of film forming gel for the delivery of 5-flurouracil: in-vitro/ex-vivo evaluation
by: Hussain Shah S.N.; Zulcaif; Syed A.; Aslam A.; Zafar N.; Arif A.
Published: (2024)

Generation of a novel ex-vivo model to study re-endothelialization
by: Azman S.S.; Yazid M.D.; Abdul Ghani N.A.; Raja Sabudin R.Z.A.; Abdul Rahman M.R.; Sulaiman N.
Published: (2023)

Tocotrienol-rich fraction (TRF) protects against retinal cell apoptosis and preserves visual behavior in rats with streptozotocin-induced diabetic retinopathy
by: Goh Y.; Sadikan M.Z.; Jaiprakash H.; Nasir N.A.A.; Agarwal R.; Iezhitsa I.; Ismail N.M.
Published: (2024)

The role of Gelam honey in accelerating reepithelialization of ex vivo corneal abrasion model
by: Azmi M.F.; Abd Ghafar N.; Che Hamzah J.; Chua K.H.; Ng S.L.
Published: (2021)

Protective effect of palm oil-derived tocotrienol-rich fraction against retinal neurodegenerative changes in rats with streptozotocin-induced diabetic retinopathy
by: Sadikan M.Z.; Nasir N.A.A.; Agarwal R.; Ismail N.M.
Published: (2020)

Curcumin prevents experimental diabetic retinopathy in rats through its hypoglycemic, antioxidant, and anti-inflammatory mechanisms
by: Gupta S.K.; Kumar B.; Nag T.C.; Agrawal S.S.; Agrawal R.; Agrawal P.; Saxena R.; Srivastava S.
Published: (2011)

Effects of Different Formulation Methods on Drug Crystallinity, Drug-Carrier Interaction, and Ex Vivo Permeation of a Ternary Solid Dispersion Containing Nisoldipine
by: Oo M.K.; Mahmood S.; Wui W.T.; Mandal U.K.; Chatterjee B.
Published: (2021)

Repetitive cryotherapy attenuates the in vitro and in vivo mononuclear cell activation response
by: Lindsay A.; Othman M.I.; Prebble H.; Davies S.; Gieseg S.P.
Published: (2016)

In vitro antioxidant and in vivo antidepressant activity of green synthesized azomethine derivatives of cinnamaldehyde
by: Chigurupati S.; Shaikh S.; Mohammad J.; Selvarajan K.; Nemala A.; Khaw C.; Teoh C.; Kee T.
Published: (2017)

Synthesis, in vitro antiurease, in vivo antinematodal activity of quinoline analogs and their in-silico study
by: Zaman K.; Rahim F.; Taha M.; Sajid M.; Hayat S.; Nawaz M.; Salahuddin M.; Iqbal N.; Khan N.U.; Shah S.A.A.; Farooq R.K.; Bahadar A.; Wadood A.; Khan K.M.
Published: (2021)

Smart nanocrystals of artemether: Fabrication, characterization, and comparative in vitro and in vivo antimalarial evaluation
by: Shah S.M.H.; Ullah F.; Khan S.; Shah S.M.M.; de Matas M.; Hhussain Z.; Minhas M.U.; AabdEel-Salam N.M.; Aassi K.H.; Iisreb M.
Published: (2016)

Effects of pure and fake honey on glucose and lipid profile in vitro and in vivo study
by: Zulkifli M.F.; Samat S.; Azam N.S.M.; Enchang F.K.; Razak A.A.; Hussein F.N.; Ismail W.I.W.
Published: (2020)

Classification of Diabetic Retinopathy Disease Using Convolutional Neural Network
by: Minarno A.E.; Mandiri M.H.C.; Azhar Y.; Bimantoro F.; Nugroho H.A.; Ibrahim Z.
Published: (2022)

Antidiabetic and antihypercholesterolemic activities of Citrus sinensis peel: In vivo study
by: Muhtadi; Haryoto; Azizah T.; Suhendi A.; Yen K.H.
Published: (2015)

In vivo study of homoeopathic preparation of Gymnema sylvestre mother tincture, 30C and 200C on streptozotocin-induced diabetic rats
by: Shukla A.; Mhaisker I.U.; Rampal K.G.; Sheshala R.
Published: (2021)

Identifying the stability of housekeeping genes to be used for the quantitative real-time PCR normalization in retinal tissue of streptozotocin-induced diabetic rats
by: Sadikan M.Z.; Nasir N.A.A.; Ibahim M.J.; Iezhitsa I.; Agarwal R.
Published: (2024)

Lactobacilli-fermented cow's milk attenuated lipopolysaccharide-induced neuroinflammation and memory impairment in vitro and in vivo
by: Musa N.H.; Mani V.; Lim S.M.; Vidyadaran S.; Abdul Majeed A.B.; Ramasamy K.
Published: (2017)

Relationship between serum and tear levels of tissue plasminogen activator and plasminogen activator inhibitor-1 in diabetic retinopathy
by: Jasmiad N.; Abd Ghani R.; Agarwal R.; Ismail Z.; Mohd Abdullah A.A.; Idorus M.Y.
Published: (2022)

Association of glycemic control with progression of diabetic retinopathy in type 2 diabetes mellitus patients in Malaysia
by: Huri H.Z.; Huey C.C.; Mustafa N.; Mohamad N.F.; Kamalden T.A.
Published: (2018)

Establishment of humanised xenograft models as in vivo study for lung metastasis of osteosarcoma
by: Khamarudin F.; Muhamad M.; Ibahim M.J.; I’zzah Wan Mohamad Zain W.N.; Aziz M.A.; Adib Ridzuan N.R.; Ab-Rahim S.
Published: (2024)

Therapeutic potentials of iridoids derived from Rubiaceae against in vitro and in vivo inflammation: A scoping review
by: Jaafar A.; Zulkipli M.A.; Mohd Hatta F.H.; Jahidin A.H.; Abdul Nasir N.A.; Hazizul Hasan M.
Published: (2024)

Therapeutic potentials of iridoids derived from Rubiaceae against in vitro and in vivo inflammation: A scoping review
by: Jaafar, et al.
Published: (2024)

Detection of Proliferative Diabetic Retinopathy in Fundus Images Using Convolution Neural Network
by: Abu Hassan H.; Yaakob M.; Ismail S.; Abd Rahman J.; Mat Rusni I.; Zabidi A.; Mohd Yassin I.; Md Tahir N.; Mohamad Shafie S.
Published: (2020)

Understanding the mode-of-action of Cassia auriculata via in silico and in vivo studies towards validating it as a long term therapy for type II diabetes
by: Mohd Fauzi F.; John C.M.; Karunanidhi A.; Mussa H.Y.; Ramasamy R.; Adam A.; Bender A.
Published: (2017)

Multifunctional hydrolysates from kenaf (Hibiscus cannabinus L.) seed protein with high antihypertensive activity in vitro and in vivo
by: Zaharuddin N.D.; Hanafi M.A.; Chay S.Y.; Hussin F.S.; Auwal S.M.; Zarei M.; Sarbini S.R.; Wan Ibadullah W.Z.; Karim R.; Saari N.
Published: (2021)

Cubosomes hydrogel containing silver based organometallic compounds for enhanced wound healing of burns: In vitro and in vivo studies
by: Farooq, et al.
Published: (2024)

In vivo antinociceptive and anti-inflammatory activities of dried and fermented processed virgin coconut oil
by: Zakaria Z.A.; Somchit M.N.; Mat Jais A.M.; Teh L.K.; Salleh M.Z.; Long K.
Published: (2011)

ANTIAPOPTOTIC EFFECT OF TAURINE AGAINST NMDA-INDUCED RETINAL EXCITOTOXICITY IN RATS
by: Lambuk L.; Iezhitsa I.; Agarwal R.; Bakar N.S.; Agarwal P.; Ismail N.M.
Published: (2019)

Chitosan based thermosensitive injectable hydrogels for controlled delivery of loxoprofen: development, characterization and in-vivo evaluation
by: Ahmad U.; Sohail M.; Ahmad M.; Minhas M.U.; Khan S.; Hussain Z.; Kousar M.; Mohsin S.; Abbasi M.; Shah S.A.; Rashid H.
Published: (2019)

Cissus hastata (Semperai) adverse anti-inflammatory response via cytokines expression with moderate cytotoxicity in vitro and in vivo towards haemorrhoid
by: Ab-Rahim S.; Sze W.A.; Wmz W.N.I.; Khan J.; Ramli N.A.; Zulkifli N.S.; Muhamad M.
Published: (2024)

New insight in improving therapeutic efficacy of antipsychotic agents: An overview of improved in vitro and in vivo performance, efficacy upgradation and future prospects
by: Ei Thu H.; Hussain Z.; Shuid A.N.
Published: (2018)

Optical Coherence Tomography (OCT) and OCT Angiography (OCTA) Biomarkers for Diabetic Retinopathy in Type 2 Diabetes Mellitus: A Scoping Review
by: Naqaweh A.; Mohamed S.O.; Saliman N.H.
Published: (2024)

In vivo efficacy of tobramycin-loaded synthetic calcium phosphate beads in a rabbit model of staphylococcal osteomyelitis
by: Lulu G.A.; Karunanidhi A.; Mohamad Yusof L.; Abba Y.; Mohd Fauzi F.; Othman F.
Published: (2018)

Targeting Differential Roles of Tumor Necrosis Factor Receptors as a Therapeutic Strategy for Glaucoma
by: Lambuk L.; Ahmad S.; Sadikan M.Z.; Nordin N.A.; Kadir R.; Nasir N.A.A.; Chen X.; Boer J.; Plebanski M.; Mohamud R.
Published: (2022)

Purtscher-like retinopathy and paracentral acute middle maculopathy following breast filler injection
by: Pee X.K.; Low A.; Ab Kahar M.E.P.I.; Mohamed S.O.; Chong Y.-J.
Published: (2023)

Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model
by: Mustafa N.W.N.A.; Ahmad R.; Ahmad Khushaini M.A.; Kamar Affendi N.H.; Ab Ghani S.M.; Tan S.K.; Ismail M.H.; Goo C.L.; Kassim M.Z.; Lim T.W.; Teh L.K.
Published: (2024)

Porous NiTi Dental Implant Fabricated by a Metal Injection Molding: An in Vivo Biocompatibility Evaluation in an Animal Model
by: Mustafa, et al.
Published: (2023)

In Vivo Antioxidant and Antiulcer Activity of Parkia speciosa Ethanolic Leaf Extract against Ethanol-Induced Gastric Ulcer in Rats
by: Al Batran R.; Al-Bayaty F.; Jamil Al-Obaidi M.M.; Abdualkader A.M.; Hadi H.A.; Ali H.M.; Abdulla M.A.
Published: (2013)

pH-responsive CAP-co-poly(methacrylic acid)-based hydrogel as an efficient platform for controlled gastrointestinal delivery: fabrication, characterization, in vitro and in vivo toxicity evaluation
by: Shah S.A.; Sohail M.; Minhas M.U.; Nisar-ur-Rehman; Khan S.; Hussain Z.; Mudassir; Mahmood A.; Kousar M.; Mahmood A.
Published: (2019)

In vivo proton magnetic resonance spectroscopy (1H-MRS) evaluation of the metabolite concentration of optic radiation in primary open angle glaucoma
by: Sidek S.; Ramli N.; Rahmat K.; Ramli N.M.; Abdulrahman F.; Kuo T.L.
Published: (2016)