Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase

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Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase

Synthesized scaffolds (1–19) of 4-quinolinyl based 1,3,4-thiadiazole-2-amine were evaluated in vitro for their α-amylase and α-glucosidase inhibition. All the newly synthesized scaffolds (1–19) were found to illustrate variable degree of inhibitory profile against α-amylase and α-glucosidase enzymes...

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Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2023
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85149061065&doi=10.1016%2fj.molstruc.2023.135173&partnerID=40&md5=5fb2cb7640406975bc1c70bb2621b487

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