2-Aminothiazole-Oxadiazole Bearing N-Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure-Activity Relationship, and Binding Conformations

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2-Aminothiazole-Oxadiazole Bearing N-Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure-Activity Relationship, and Binding Conformations

A multi-step synthesis of novel bi-heterocyclic N-arylated butanamides was consummated through a convergent strategy and the structures of these medicinal scaffolds, 7a–h, were corroborated using spectral techniques. The in vitro analysis of these hybrid molecules revealed their potent tyrosinase in...

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Bibliographic Details
Published in:	Chemistry and Biodiversity
Main Author:	Raza H.; Rehman Sadiq Butt A.; Athar Abbasi M.; Aziz-ur-Rehman; Zahra Siddiqui S.; Hassan M.; Adnan Ali Shah S.; Ja Kim S.
Format:	Article
Language:	English
Published:	John Wiley and Sons Inc 2023
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146447713&doi=10.1002%2fcbdv.202201019&partnerID=40&md5=98c0f4a01d5482f9a3e94ed5bee9d376

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