2-Aminothiazole-Oxadiazole Bearing N-Arylated Butanamides: Convergent Synthesis, Tyrosinase Inhibition, Kinetics, Structure-Activity Relationship, and Binding Conformations
A multi-step synthesis of novel bi-heterocyclic N-arylated butanamides was consummated through a convergent strategy and the structures of these medicinal scaffolds, 7a–h, were corroborated using spectral techniques. The in vitro analysis of these hybrid molecules revealed their potent tyrosinase in...
| Published in: | Chemistry and Biodiversity |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
John Wiley and Sons Inc
2023
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85146447713&doi=10.1002%2fcbdv.202201019&partnerID=40&md5=98c0f4a01d5482f9a3e94ed5bee9d376 |