The effect of palm oil-derived tocotrienol-rich fraction in preserving normal retinal vascular diameter in streptozotocin-induced diabetic rats

Purpose: Angiogenesis in diabetic retinopathy (DR) is associated with increased retinal expression of angiopoietin-2 (Ang-2) and protein kinase C (PKC). Tocotrienol-rich fraction (TRF) has been shown to reduce the expression vascular endothelial growth factor (VEGF) in several experimental models. H...

Full description

Bibliographic Details
Published in:Graefe's Archive for Clinical and Experimental Ophthalmology
Main Authors: Abdul Ghani N.A., Abdul Nasir N.A., Lambuk L., Sadikan M.Z., Agarwal R., Ramli N.
Format: Article
Language:English
Published: Springer Science and Business Media Deutschland GmbH 2023
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85145898569&doi=10.1007%2fs00417-022-05965-3&partnerID=40&md5=0826fa4dfa2fe04f1c2b5bcb99688fa1