Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives

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Multipotent Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: Synthesis, Biological Analysis and Molecular Docking Study of Benzimidazole-Based Thiazole Derivatives

Twenty-four analogues of benzimidazole-based thiazoles (1–24) were synthesized and assessed for their in vitro acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) inhibitory potential. All analogues were found to exhibit good inhibitory potential against cholinesterase enzymes, having IC50...

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Bibliographic Details
Published in:	Molecules
Main Author:	Hussain R.; Ullah H.; Rahim F.; Sarfraz M.; Taha M.; Iqbal R.; Rehman W.; Khan S.; Shah S.A.A.; Hyder S.; Alhomrani M.; Alamri A.S.; Abdulaziz O.; Abdelaziz M.A.
Format:	Article
Language:	English
Published:	MDPI 2022
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85138432376&doi=10.3390%2fmolecules27186087&partnerID=40&md5=00a737ae1c7b971380e00250d596818f

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