Efficient Synthesis of 4-Bromo-N-(1-phenylethyl)benzamide, Arylation by Pd(0) Catalyst, Characterization and DFT Study

• Published in: ChemistrySelect
• Main Author: Raza Shah A.; Rasool N.; Bılal M.; Mubarık A.; Alı Hashmı M.; Nadeem Akhtar M.; Imran M.; Ahmad G.; Siddiqa A.; Adnan Alı Shah S.
• Format: Article
• Language: English
• Published: John Wiley and Sons Inc 2022
• Online Access: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135826802&doi=10.1002%2fslct.202200861&partnerID=40&md5=85c76ec5f31ab2fe11520228935626b1

The (S)-4-bromo-N-(1-phenylethyl)benzamide (3) was synthesized in excellent yield (93 %) by the reaction of 4-bromobenzoic acid (1) and (S)-1-phenylethanamine (2) with the coupling reagent titanium tetrachloride (TiCl4). Further, the Pd(0) catalyst was employed to form (S)-4-bromo-N-(1-phenylethyl)benzamide analogues (5 a-i) by reacting various aryl boronic acids with 4-bromo-N-(1-phenylethyl)benzamide (3) in moderate to good yields (62-89 %). Furthermore, DFT studies were carried out to compute optimized geometries, frontier molecular orbitals, polarizability (α), hyperpolarizability (β), MESP, reactivity descriptors, and NMR spectra. The measured NMR values matched the experimental NMR values well. In this series (5 a-i), we predicted that the highest energy difference between the HOMO-LUMO of compound (5 a) has 4.98 eV, resulting in a more stable compound, and compound (5 g) has the lowest energy difference between the HOMO-LUMO 4.63 eV, resulting in the least stable compound. Compound (5h) has the highest hyperpolarizability (β) value, exhibits a better non-linear optical (NLO) behaviour compared as compare to other synthesized compounds in the series. © 2022 Wiley-VCH GmbH.