Efficient Synthesis of 4-Bromo-N-(1-phenylethyl)benzamide, Arylation by Pd(0) Catalyst, Characterization and DFT Study

The (S)-4-bromo-N-(1-phenylethyl)benzamide (3) was synthesized in excellent yield (93 %) by the reaction of 4-bromobenzoic acid (1) and (S)-1-phenylethanamine (2) with the coupling reagent titanium tetrachloride (TiCl4). Further, the Pd(0) catalyst was employed to form (S)-4-bromo-N-(1-phenylethyl)b...

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Bibliographic Details
Published in:ChemistrySelect
Main Author: Raza Shah A.; Rasool N.; Bılal M.; Mubarık A.; Alı Hashmı M.; Nadeem Akhtar M.; Imran M.; Ahmad G.; Siddiqa A.; Adnan Alı Shah S.
Format: Article
Language:English
Published: John Wiley and Sons Inc 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85135826802&doi=10.1002%2fslct.202200861&partnerID=40&md5=85c76ec5f31ab2fe11520228935626b1