Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1

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Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1

Burkholderiapseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that the toxin binds in the cleft between t...

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Bibliographic Details
Published in:	Communications Biology
Main Author:	Mobbs G.W.; Aziz A.A.; Dix S.R.; Blackburn G.M.; Sedelnikova S.E.; Minshull T.C.; Dickman M.J.; Baker P.J.; Nathan S.; Raih M.F.; Rice D.W.
Format:	Article
Language:	English
Published:	Nature Research 2022
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127296518&doi=10.1038%2fs42003-022-03186-2&partnerID=40&md5=42193cdc9b8ebc9e5ae18aa38e51237d

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