Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1
Burkholderiapseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that the toxin binds in the cleft between t...
| Published in: | Communications Biology |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Nature Research
2022
|
| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127296518&doi=10.1038%2fs42003-022-03186-2&partnerID=40&md5=42193cdc9b8ebc9e5ae18aa38e51237d |