Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1

Molecular basis of specificity and deamidation of eIF4A by Burkholderia Lethal Factor 1

Burkholderiapseudomallei lethal factor 1 (BLF1) exhibits site-specific glutamine deamidase activity against the eukaryotic RNA helicase, eIF4A, thereby blocking mammalian protein synthesis. The structure of a complex between BLF1 C94S and human eIF4A shows that the toxin binds in the cleft between t...

Full description

Bibliographic Details
Published in:Communications Biology
Main Author: Mobbs G.W.; Aziz A.A.; Dix S.R.; Blackburn G.M.; Sedelnikova S.E.; Minshull T.C.; Dickman M.J.; Baker P.J.; Nathan S.; Raih M.F.; Rice D.W.
Format: Article
Language:English
Published: Nature Research 2022
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127296518&doi=10.1038%2fs42003-022-03186-2&partnerID=40&md5=42193cdc9b8ebc9e5ae18aa38e51237d

Internet

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85127296518&doi=10.1038%2fs42003-022-03186-2&partnerID=40&md5=42193cdc9b8ebc9e5ae18aa38e51237d

Similar Items