Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes

QR Code

Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes

In the search of potent α-amylase inhibitors, we have synthesized seventeen derivatives of 2-mercaptobenzimidazole bearing sulfonamide (1–17) and evaluated for their α-amylase inhibitory potential. All synthesized compounds display a variable degree of α-amylase activity having IC50 values ranging b...

Full description

Bibliographic Details
Published in:	Journal of Molecular Structure
Main Author:	Hussain S.; Taha M.; Rahim F.; Hayat S.; Zaman K.; Iqbal N.; Selvaraj M.; Sajid M.; Bangesh M.A.; Khan F.; Khan K.M.; Uddin N.; Shah S.A.A.; Ali M.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2021
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101323909&doi=10.1016%2fj.molstruc.2021.130029&partnerID=40&md5=2a3ee29ff71e8775509250548c6f68a0

Similar Items

Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
by: Ullah W.; Rahim F.; Hayat S.; Ullah H.; Taha M.; Khan S.; Khaliq A.; Bibi S.; Gohar O.; Iqbal N.; Shah S.A.A.; Khan K.M.
Published: (2024)

Benzimidazole Bearing Thiosemicarbazone Derivatives Act as Potent α-Amylase and α-Glucosidase Inhibitors; Synthesis, Bioactivity Screening and Molecular Docking Study
by: Ullah H.; Khan S.; Rahim F.; Taha M.; Iqbal R.; Sarfraz M.; Shah S.A.A.; Sajid M.; Awad M.F.; Omran A.; Albalawi M.A.; Abdelaziz M.A.; Al Areefy A.; Jafri I.
Published: (2022)

Synthesis, In Vitro α-Amylase Activity, and Molecular Docking Study of New Benzimidazole Derivatives
by: Ullah H.; Ullah H.; Taha M.; Khan F.; Rahim F.; Uddin I.; Sarfraz M.; Shah S.A.A.; Aziz A.; Mubeen S.
Published: (2021)

Synthesis, biological evaluation and molecular docking study of benzimidazole derivatives as α-glucosidase inhibitors and anti-diabetes candidates
by: Hayat S.; Ullah H.; Rahim F.; Ullah I.; Taha M.; Iqbal N.; Khan F.; Khan M.S.; Shah S.A.A.; Wadood A.; Sajid M.; Abdalla A.N.
Published: (2023)

Synthesis of new arylhydrazide bearing Schiff bases/thiazolidinone: α-Amylase, urease activities and their molecular docking studies
by: Rahim F.; Taha M.; Ullah H.; Wadood A.; Selvaraj M.; Rab A.; Sajid M.; Shah S.A.A.; Uddin N.; Gollapalli M.
Published: (2019)

Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies
by: Taha M.; Sultan S.; Imran S.; Rahim F.; Zaman K.; Wadood A.; Ur Rehman A.; Uddin N.; Mohammed Khan K.
Published: (2019)

Synthesis and molecular docking studies of potent α-glucosidase inhibitors based on biscoumarin skeleton
by: Khan K.M.; Rahim F.; Wadood A.; Kosar N.; Taha M.; Lalani S.; Khan A.; Fakhri M.I.; Junaid M.; Rehman W.; Khan M.; Perveen S.; Sajid M.; Choudhary M.I.
Published: (2014)

Synthesis, α-amylase inhibitory potential and molecular docking study of indole derivatives
by: Taha M.; Baharudin M.S.; Ismail N.H.; Imran S.; Khan M.N.; Rahim F.; Selvaraj M.; Chigurupati S.; Nawaz M.; Qureshi F.; Vijayabalan S.
Published: (2018)

New triazinoindole bearing thiazole/oxazole analogues: Synthesis, α-amylase inhibitory potential and molecular docking study
by: Rahim F.; Tariq S.; Taha M.; Ullah H.; Zaman K.; Uddin I.; Wadood A.; Khan A.A.; Rehman A.U.; Uddin N.; Zafar S.; Shah S.A.A.
Published: (2019)

Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats
by: Taha M.; Imran S.; Salahuddin M.; Iqbal N.; Rahim F.; Uddin N.; Shehzad A.; Khalid Farooq R.; Alomari M.; Mohammed Khan K.
Published: (2021)

Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023)

Thiazole based carbohydrazide derivatives as α-amylase inhibitor and their molecular docking study
by: Taha M.; Irshad M.; Imran S.; Rahim F.; Selvaraj M.; Almandil N.B.; Mosaddik A.; Chigurupati S.; Nawaz F.; Ismail N.H.; Ibrahim M.
Published: (2019)

New benzimidazole based Schiff bases as potent anti-alzheimer agents: Synthesis, bio-evaluation and molecular docking study
by: Othman M.S.; Hayat S.; Rahim F.; Taha M.; Sajid M.; Khan S.; Iqbal W.; Shah S.A.A.; Fareid M.A.; Aboelnaga S.M.; Abdel-Hafez L.J.; Hafez M.M.
Published: (2024)

Synthesis of piperazine sulfonamide analogs as diabetic-II inhibitors and their molecular docking study
by: Taha M.; Irshad M.; Imran S.; Chigurupati S.; Selvaraj M.; Rahim F.; Ismail N.H.; Nawaz F.; Khan K.M.
Published: (2017)

Triazinoindole analogs as potent inhibitors of α-glucosidase: Synthesis, biological evaluation and molecular docking studies
by: Rahim F.; Ullah K.; Ullah H.; Wadood A.; Taha M.; Rehman A.U.; Uddin I.; Ashraf M.; Shaukat A.; Rehman W.; Hussain S.; Khan K.M.
Published: (2015)

New benzoxazole-based sulphonamide hybrids analogs as potent inhibitors of α-amylase and α-glucosidase: Synthesis and in vitro evaluation along with in silico study
by: Khan S.; Rahim F.; Rehman W.; Nawaz M.; Taha M.; Fazil S.; Hussain R.; Adnan Ali Shah S.; Abdellatif M.H.
Published: (2022)

Isatin based thiosemicarbazide derivatives as potential inhibitor of α-glucosidase, synthesis and their molecular docking study
by: Rahim F.; Taha M.; Iqbal N.; Hayat S.; Qureshi F.; Uddin I.; Zaman K.; Rab A.; Wadood A.; Uddin N.; Nawaz M.; Shah S.A.A.; Khan K.M.
Published: (2020)

Biologically Potent Benzimidazole-Based-Substituted Benzaldehyde Derivatives as Potent Inhibitors for Alzheimer’s Disease along with Molecular Docking Study
by: Adalat B.; Rahim F.; Rehman W.; Ali Z.; Rasheed L.; Khan Y.; Farghaly T.A.; Shams S.; Taha M.; Wadood A.; Shah S.A.A.; Abdellatif M.H.
Published: (2023)

Novel acyl hydrazide derivatives of polyhydroquinoline as potent anti-diabetic and anti-glycating agents: Synthesis, in vitro α-amylase, α-glucosidase inhibition and anti-glycating activity with molecular docking insights
by: Ur Rahman S.; Alam A.; Parveen Z.; Zainab; Assad M.; Adnan Ali Shah S.; Rafiq H.; Ayaz M.; Latif A.; Naveed Umar M.; Ali M.; Ahmad M.
Published: (2024)

Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Ainaa I.; Selvaraj M.; baharudin M.; Ali M.; Khan K.M.; Uddin N.
Published: (2017)

Synthesis, α-amylase inhibition and molecular docking study of bisindolylmethane sulfonamide derivatives
by: Taha M.; Noreen T.; Imran S.; Nawaz F.; Chigurupati S.; Selvaraj M.; Rahim F.; Hadiani Ismail N.; Kumar A.; Mosaddik A.; Alghamdi A.M.; Abdulrahman nasser alqahtani Y.; Abdulrahman nasser alqahtani A.
Published: (2019)

Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors
by: Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rashwan H.; Farhanah F.U.; Rahim F.; Kesavanarayanan K.S.; Ali M.
Published: (2015)

Synthesis and biological evaluation of indole derivatives as α-amylase inhibitor
by: Imran S.; Taha M.; Selvaraj M.; Ismail N.H.; Chigurupati S.; Mohammad J.I.
Published: (2017)

Synthesis and study of the α-amylase inhibitory potential of thiadiazole quinoline derivatives
by: Taha M.; Tariq Javid M.; Imran S.; Selvaraj M.; Chigurupati S.; Ullah H.; Rahim F.; Khan F.; Islam Mohammad J.; Mohammed Khan K.
Published: (2017)

Synthesis, in vitro alpha-glucosidase inhibitory potential of benzimidazole bearing bis-Schiff bases and their molecular docking study
by: Rahim F.; Zaman K.; Taha M.; Ullah H.; Ghufran M.; Wadood A.; Rehman W.; Uddin N.; Shah S.A.A.; Sajid M.; Nawaz F.; Khan K.M.
Published: (2020)

Synthesis, α-glucosidase inhibitory activity and in silico study of tris-indole hybrid scaffold with oxadiazole ring: As potential leads for the management of type-II diabetes mellitus
by: Taha M.; Rahim F.; Imran S.; Ismail N.H.; Ullah H.; Selvaraj M.; Javid M.T.; Salar U.; Ali M.; Khan K.M.
Published: (2017)

New thiazole-based thiazolidinone derivatives: Synthesis, in vitro α-amylase, α-glucosidase activities and silico molecular docking study
by: Khan S.; Ullah H.; Rahim F.; Taha M.; Hussain R.; Khan M.S.; Ali H.; Khan M.U.; Shah S.A.A.; Khan K.M.
Published: (2022)

Synthesis of novel indazole derivatives as inhibitors of diabetics II along with molecular docking and simulation study
by: Al-Nasser F.; Taha M.; Rahim F.; Adalat B.; Chigurupati S.; Nawaz M.; Ajmal A.; Wadood A.; Uddin N.; Khan K.M.; Ali shah S.A.; Felemban S.G.; Venugopal V.
Published: (2025)

Exploring diabetics II inhibitors based on benzodioxin derivatives, structure activity relationship, molecular docking and ADME property study
by: Al-Abdulbaqi M.A.; Taha M.; Rahim F.; Uddin I.; Uddin N.; Wadood A.; Haq S.; Iqbal N.; Khan K.M.; Ali shah S.A.; Ali M.
Published: (2024)

Synthesis of new 1,2-disubstituted benzimidazole analogs as potent inhibitors of β-Glucuronidase and in silico study
by: Taha M.; Ahmad Khan A.; Rahim F.; Imran S.; Salahuddin M.; Uddin N.; Mohammed Khan K.; Adnan Ali Shah S.; Zafar A.; Amiruddin Zakaria Z.
Published: (2022)

Synthesis, molecular docking studies of hybrid benzimidazole as α-glucosidase inhibitor
by: Zawawi N.K.N.A.; Taha M.; Ahmat N.; Ismail N.H.; Wadood A.; Rahim F.
Published: (2017)

Synthesis of novel indazole derivatives as inhibitors of diabetics II along with molecular docking and simulation study
by: Al-Nasser, et al.
Published: (2025)

Syntheses, in vitro evaluation and molecular docking studies of 5-bromo-2-aryl benzimidazoles as α-glucosidase inhibitors
by: Arshad T.; Khan K.M.; Rasool N.; Salar U.; Hussain S.; Tahir T.; Ashraf M.; Wadood A.; Riaz M.; Perveen S.; Taha M.; Ismail N.H.
Published: (2016)

Synthesis, molecular docking and anti-diabetic studies of novel benzimidazole-pyrazoline hybrid molecules
by: Ibraheem F.; Ahmad M.; Ashfaq U.A.; Aslam S.; Khan Z.A.; Sultan S.
Published: (2020)

Synthesis of novel triazinoindole-based thiourea hybrid: A study on α-glucosidase inhibitors and their molecular docking
by: Taha M.; Alshamrani F.J.; Rahim F.; Hayat S.; Ullah H.; Zaman K.; Imran S.; Khan K.M.; Naz F.
Published: (2019)

Cu(II) complexes based on benzimidazole ligands: synthesis, characterization, DFT, molecular docking & bioactivity study
by: Hamali, et al.
Published: (2024)

Synthesis, in vitro biological screening and docking study of benzo[d]oxazole bis Schiff base derivatives as a potent anti-Alzheimer agent
by: Taha M.; Rahim F.; Zaman K.; Anouar E.H.; Uddin N.; Nawaz F.; Sajid M.; Khan K.M.; Shah A.A.; Wadood A.; Rehman A.U.; Alhibshi A.H.
Published: (2023)

New Quinoline Analogues: As Potential Diabetics Inhibitors and Molecular Docking Study
by: Taha M.; Salahuddin M.; Rahim F.; Imran S.; Hussain S.; Uddin N.; Khan K.M.
Published: (2024)

Synthesis of benzimidazole derivatives and their antiglycation, antioxidant, antiurease and molecular docking study
by: Taha M.; Rahim F.; Adalath B.; Imran S.; Mohammed Khan K.; Adnan Ali shah S.; Uddin N.; Nawaz M.; Break M.K.B.; Magam S.M.; Alqarni S.
Published: (2024)

Synthesis, in vitro evaluation and molecular docking studies of thiazole derivatives as new inhibitors of α-glucosidase
by: Rahim F.; Ullah H.; Javid M.T.; Wadood A.; Taha M.; Ashraf M.; Shaukat A.; Junaid M.; Hussain S.; Rehman W.; Mehmood R.; Sajid M.; Khan M.N.; Khan K.M.
Published: (2015)