Synthesis of benzimidazole derivatives as potent inhibitors for α-amylase and their molecular docking study in management of type-II diabetes
In the search of potent α-amylase inhibitors, we have synthesized seventeen derivatives of 2-mercaptobenzimidazole bearing sulfonamide (1–17) and evaluated for their α-amylase inhibitory potential. All synthesized compounds display a variable degree of α-amylase activity having IC50 values ranging b...
Published in: | Journal of Molecular Structure |
---|---|
Main Author: | Hussain S.; Taha M.; Rahim F.; Hayat S.; Zaman K.; Iqbal N.; Selvaraj M.; Sajid M.; Bangesh M.A.; Khan F.; Khan K.M.; Uddin N.; Shah S.A.A.; Ali M. |
Format: | Article |
Language: | English |
Published: |
Elsevier B.V.
2021
|
Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85101323909&doi=10.1016%2fj.molstruc.2021.130029&partnerID=40&md5=2a3ee29ff71e8775509250548c6f68a0 |
Similar Items
-
Synthesis of Indole Based Sulfonamide Derivatives as potent inhibitors of α-glucosidase and α-amylase in management of type-II diabetes
by: Ullah W.; Rahim F.; Hayat S.; Ullah H.; Taha M.; Khan S.; Khaliq A.; Bibi S.; Gohar O.; Iqbal N.; Shah S.A.A.; Khan K.M.
Published: (2024) -
Synthesis of benzimidazole derivatives as potent β-glucuronidase inhibitors
by: Taha M.; Ismail N.H.; Imran S.; Selvaraj M.; Rashwan H.; Farhanah F.U.; Rahim F.; Kesavanarayanan K.S.; Ali M.
Published: (2015) -
Synthesis, in vitro evaluation and molecular docking studies of hybrid 4-quinolinyl bearing 1,3,4-thiadiazole-2-amine as a new inhibitor of α-amylase and α-glucosidase
by: Taha M.; Khan A.A.; Rahim F.; Hayat S.; Imran S.; Iqbal N.; Uddin N.; Khan K.M.; Anouar E.H.; Farooq R.K.; Nawaz M.; Shah S.A.A.
Published: (2023) -
Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies
by: Taha M.; Sultan S.; Imran S.; Rahim F.; Zaman K.; Wadood A.; Ur Rehman A.; Uddin N.; Mohammed Khan K.
Published: (2019) -
Evaluation and docking of indole sulfonamide as a potent inhibitor of α-glucosidase enzyme in streptozotocin –induced diabetic albino wistar rats
by: Taha M.; Imran S.; Salahuddin M.; Iqbal N.; Rahim F.; Uddin N.; Shehzad A.; Khalid Farooq R.; Alomari M.; Mohammed Khan K.
Published: (2021)