Convergent synthesis of carbonic anhydrase inhibiting bi-heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies

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Convergent synthesis of carbonic anhydrase inhibiting bi-heterocyclic benzamides: Structure–activity relationship and mechanistic explorations through enzyme inhibition, kinetics, and computational studies

By using a convergent methodology, a novel series of N-arylated 4-yl-benzamides containing a bi-heterocyclic thiazole–triazole core was synthesized, and the structures of these hybrid molecules, 9a–k, were corroborated through spectral analyses. The in vitro studies of these multifunctional molecule...

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Bibliographic Details
Published in:	Journal of Heterocyclic Chemistry
Main Author:	Khan F.M.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Sadiq Butt A.R.; Raza H.; Zafar A.; Ali Shah S.A.; Shahid M.; Seo S.-Y.
Format:	Article
Language:	English
Published:	HeteroCorporation 2021
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85100860135&doi=10.1002%2fjhet.4240&partnerID=40&md5=5810164116b32e93ad79702e0679d85d

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