Limited expression of non-integrating CpG-free plasmid is associated with increased nucleosome enrichment
CpG-free pDNA was reported to facilitate sustained transgene expression with minimal inflammation in vivo as compared to CpG-containing pDNA. However, the expression potential and impact of CpG-free pDNA in in vitro model have never been described. Hence, in this study, we analyzed the transgene exp...
| Published in: | PLoS ONE |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science
2020
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85098924786&doi=10.1371%2fjournal.pone.0244386&partnerID=40&md5=13db0f34181ffc31ee3e0e9ae1bf6f2f |