Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors

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Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors

Four benzamide derivatives (5a, 5b, 8a, 8b) bearing heterocyclic furan and piperazine ring have been synthesized and evaluated for enzyme inhibition and hemolytic activity. Initial 4-(chloromethyl)benzoyl chloride (1) and 3-(chloromethyl)benzoyl chloride (6) were stirred with benzyl amine (2a) and c...

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Bibliographic Details
Published in:	Pharmaceutical Chemistry Journal
Main Author:	Abbasi M.A.; Irshad M.; Aziz-ur-Rehman; Siddiqui S.Z.; Junaid H.M.; Shah S.A.A.; Ashraf M.
Format:	Article
Language:	English
Published:	Springer 2020
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091726412&doi=10.1007%2fs11094-020-02247-2&partnerID=40&md5=bfacbc29434371eaa4aec9bf5c40f8f7

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