Synthesis and Structure-Activity Relationship of 1-(2-Furoyl)Piperazine Bearing Benzamides as Butyrylcholinesterase Inhibitors
Four benzamide derivatives (5a, 5b, 8a, 8b) bearing heterocyclic furan and piperazine ring have been synthesized and evaluated for enzyme inhibition and hemolytic activity. Initial 4-(chloromethyl)benzoyl chloride (1) and 3-(chloromethyl)benzoyl chloride (6) were stirred with benzyl amine (2a) and c...
| Published in: | Pharmaceutical Chemistry Journal |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Springer
2020
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091726412&doi=10.1007%2fs11094-020-02247-2&partnerID=40&md5=bfacbc29434371eaa4aec9bf5c40f8f7 |