4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation

QR Code

4-(2-(1H-Benzo[d]imidazol-2-ylthio) acetamido)-N-(substituted phenyl)benzamides: Design, synthesis and biological evaluation

Background: Dihydrofolate reductase (DHFR) is an important target for antimetabolite class of antimicrobials because it participates in purine synthesis. 2-mercaptobenzimidazole (2MBI) has similar structural features as purine nucleotides. Given that benzimidazole and similar heteroaromatics have be...

Full description

Bibliographic Details
Published in:	BMC Chemistry
Main Author:	Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Format:	Article
Language:	English
Published:	BioMed Central Ltd 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85091148352&doi=10.1186%2fs13065-019-0533-7&partnerID=40&md5=dd621e6f2c49c8b9aca88b36cdd71944

Similar Items

Design, synthesis and therapeutic potential of 3-(2-(1H-benzo[d]imidazol-2-ylthio)acetamido)-N-(substituted phenyl)benzamide analogues
by: Tahlan S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2018)

Synthesis, characterization, biological evaluation and molecular docking studies of 2-(1H-benzo[d]imidazol-2-ylthio)-N-(substituted 4-oxothiazolidin-3-yl) acetamides
by: Yadav S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Selvaraj M.
Published: (2017)

Synthesis and evaluation of antimicrobial, antitubercular and anticancer activities of 2-(1-benzoyl-1H-benzo[d]imidazol-2-ylthio)-N-substituted acetamides
by: Yadav S.; Lim S.M.; Ramasamy K.; Vasudevan M.; Shah S.A.A.; Mathur A.; Narasimhan B.
Published: (2018)

Design, synthesis and biological evaluation of 3-(2-aminooxazol-5-yl)-2H-chromen-2-one derivatives
by: Kakkar S.; Kumar S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

Synthesis and biological evaluation of heterocyclic 1,2,4-triazole scaffolds as promising pharmacological agents
by: Kumari M.; Tahlan S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Kakkar S.
Published: (2021)

Synthesis and biological profile of substituted benzimidazoles
by: Vashist N.; Sambi S.S.; Narasimhan B.; Kumar S.; Lim S.M.; Shah S.A.A.; Ramasamy K.; Mani V.
Published: (2018)

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors
by: Zeb A.; Siddiqui S.Z.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Imran S.; Raza H.; Kim S.J.; Parveen R.; Abbas G.
Published: (2025)

Synthesis, enzyme inhibitory kinetics, & computational studies of N-(substituted phenyl)-(5-(3,4-dichlorobenzyl)-4-(4-chlorophenyl)-4H-1,2,4-triazol-3-ylthio)methylbenzamides: As potent alkaline phosphatase inhibitors
by: Zeb, et al.
Published: (2025)

Benzoxazole derivatives: design, synthesis and biological evaluation
by: Kakkar S.; Tahlan S.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.; Narasimhan B.
Published: (2018)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Nazir M.; Muhammad S.; Raza H.; Shah S.A.A.; Shahid M.; Chaudhry A.R.; Kim S.J.
Published: (2025)

Multi-step synthesis, kinetics and in silico explorations of indole-Phenyl-1,2,4-triazole Bi-heterocyclic hybrids unified with 3-substituted benzamides as elastase inhibitors
by: Shakila; Abbasi, et al.
Published: (2025)

Synthesis, spectral analysis and pharmacological study of N’-substituted-2-(5-((2,4-dimethylphenoxy)methyl)-1,3,4-oxadiazol-2-ylthio)acetohydrazides
by: Rasool S.; Aziz-ur-Rehman; Abbasi M.A.; Siddiqui S.Z.; Shah S.A.A.
Published: (2016)

Synthesis, antimicrobial and cytotoxic evaluation of 4-(1-aryl-5-halo-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2017)

Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N'-(substituted)-4-(butan-2-lideneamino)benzohydrazides
by: Saini M.; Kumar P.; Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Narasimhan B.
Published: (2014)

Synthesis, molecular modelling and biological significance of N-(4-(4-bromophenyl) thiazol-2-yl)-2-chloroacetamide derivatives as prospective antimicrobial and antiproliferative agents
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

Synthesis, antimicrobial, anticancer, antiviral evaluation and QSAR studies of 4-(1-aryl-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides
by: Kumar M.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; Clercq E.D.; Narasimhan B.
Published: (2014)

Design, synthesis and biological profile of heterocyclic benzimidazole analogues as prospective antimicrobial and antiproliferative agents
by: Tahlan S.; Kumar S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Pathania R.; Narasimhan B.
Published: (2019)

4-(1-Aryl-5-chloro-2-oxo-1,2-dihydro-indol-3-ylideneamino)-N-substituted benzene sulfonamides: Synthesis, antimicrobial, anticancer evaluation and QSAR studies
by: Kumar M.; Narasimhan B.; Kumar P.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.
Published: (2014)

Synthesis Of Some N-(Un/Substituted-Phenyl)-2-(4-Phenyl-1-Piperazinyl)Acetamides as Possible Antibacterial and Anticancer Agents with Mild Cytotoxicity
by: Abbasi M.A.; Nazir M.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Saleem R.S.Z.; Shahid M.; Mirza B.; Ismail H.
Published: (2022)

Design, synthesis, sar study, antimicrobial and anticancer evaluation of novel 2-mercaptobenzimidazole azomethine derivatives
by: Tahlan S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2020)

2-mercaptobenzimidazole schiff bases: Design, synthesis, antimicrobial studies and anticancer activity on HCT-116 cell line
by: Tahlan S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Shah S.A.A.
Published: (2019)

N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: Synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies
by: Kumar P.; Narasimhan B.; Ramasamy K.; Mani V.; Mishra R.K.; Majeed A.B.A.; De Clercq E.
Published: (2013)

Biology-oriented drug synthesis (BIODS): In vitro β-glucuronidase inhibitory and in silico studies on 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl carboxylate derivatives
by: Salar U.; Khan K.M.; Taha M.; Ismail N.H.; Ali B.; Qurat-ul-Ain; Perveen S.; Ghufran M.; Wadood A.
Published: (2017)

Innovative cholinergic scaffolds, synthesis, and characterization of substituted 1,2,4-triazole-3-ylthio-N-acetamides and their in silico studies: supplement against neurodegenerative disease
by: Arfan M.; Siddiqui S.Z.; Abbasi M.A.; Aziz-ur-Rehman; Saad S.M.; Shah S.A.A.; Ashraf M.; Hussain S.; Ali F.; Solangi M.; Khan K.M.
Published: (2023)

Biology-oriented drug synthesis (BIODS) of 2-(2-methyl-5-nitro-1H-imidazol-1-yl)ethyl aryl ether derivatives, in vitro α-amylase inhibitory activity and in silico studies
by: Taha M.; Imran S.; Ismail N.H.; Selvaraj M.; Rahim F.; Chigurupati S.; Ullah H.; Khan F.; Salar U.; Javid M.T.; Vijayabalan S.; Zaman K.; Khan K.M.
Published: (2017)

Synthesis and corrosion inhibition studies of N-((4 and 3-chlorophenyl) carbamothioyl) benzamide in 1M H2SO4
by: Zulkifli N.Z.; Kassim K.; Nordin N.A.
Published: (2017)

4-(4-Bromophenyl)-Thiazol-2-Amine derivatives: Synthesis, biological activity and molecular docking study with ADME profile
by: Sharma D.; Kumar S.; Narasimhan B.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.
Published: (2019)

Synthesis, pharmacological screening & computational analysis of some 2-(1H-Indol-3-yl)-N'-[(un)substituted phenylmethylidene] acetohydrazides & 2-(1H-Indol-3-yl)-N'-[(un)substituted benzoyl/2-Thienylcarbonyl]acetohydrazides
by: Rubab K.; Abbasi M.A.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Qurat-Ul-Ain; Ahmad I.; Lodhi M.A.; Ghufran M.; Shahid M.; Fatima H.
Published: (2017)

Synthesis, In Vitro, and In Silico Studies of N-(Substituted-Phenyl)-3-(4-Phenyl-1-Piperazinyl)propanamides as Potent Alkaline Phosphatase Inhibitors
by: Abbasi M.A.; Nazir M.; Aziz-ur-Rehman; Siddiqui S.Z.; Raza H.; Zafar A.; Shah S.A.A.; Shahid M.
Published: (2021)

Synthesis and α-glucosidase inhibition activity of 2-[3-(Benzoyl/4-bromobenzoyl)-4-hydroxy-1,1-dioxido-2h-benzo[e][1,2]thiazin-2-yl]-n-arylacetamides: An in silico and biochemical approach
by: Saddique F.A.; Aslam S.; Ahmad M.; Ashfaq U.A.; Muddassar M.; Sultan S.; Taj S.; Hussain M.; Lee D.S.; Zaki M.E.A.
Published: (2021)

Design, synthesis and biological potential of 5-(2-amino-6-(3/4-bromophenyl)pyrimidin-4-yl)benzene-1,3-diol scaffolds as promising antimicrobial and anticancer agents
by: Kumar S.; Narasimhan B.; Lim S.M.; Ramasamy K.; Mani V.; Ali Shah S.A.
Published: (2019)

Design, synthesis and computational studies of N-(substituted-phenyl)-4-(4-phenyl-1-piperazinyl)butanamides as potent anti-melanogenic and tyrosinase inhibitors
by: Raza H.; Abbasi M.A.; Rehman A.-U.; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Shahid M.; Hong H.; Seo S.-Y.
Published: (2020)

Synthesis, Kinetics and Computational Explorations of 4-Phenylpiperazine Bearing N-(Aryl)-3-substituted-benzamides as Auspicious Tyrosinase Inhibitors
by: Zeb A.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Javed Q.; Rafiq M.; Ali A.; Shah S.A.A.; Kloczkowski A.
Published: (2024)

Synthesis of promising antibacterial and antifungal agents: 2-[[(4-Chlorophenyl)sulfonyl](2,3-dihydro-1,4-benzodioxin-6-yl)amino]-N(un/substituted-phenyl)acetamides
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Nazir M.; Ali Shah S.A.; Shahid M.
Published: (2020)

N-(5-Methyl-1,3-Thiazol-2-yl)-2-{[5-((Un)Substituted- Phenyl)1,3,4-Oxadiazol-2-yl]Sulfanyl}acetamides. Unique Biheterocycles as Promising Therapeutic Agents
by: Abbasi M.A.; Ramzan M.S.; Aziz-ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Hassan M.; Seo S.-Y.; Ashraf M.; Mirza B.; Ismail H.
Published: (2018)

Synthesis of novel N-(2,3-dihydro-1,4-benzodioxin-6-yl)-2-{[5-(un/substituted-phenyl)-1,3,4-oxadiazol-2-yl]sulfanyl}acetamides as potent antibacterial agents
by: Abbasi M.A.; Irshad M.; Aziz-Ur-Rehman; Siddiqui S.Z.; Shah S.A.A.; Shahid M.
Published: (2022)

Synthesis, molecular docking, dynamic simulations, kinetic mechanism, cytotoxicity evaluation of N-(substituted-phenyl)-4-{(4-[(E)-3-phenyl-2-propenyl]-1-piperazinyl} butanamides as tyrosinase and melanin inhibitors: In vitro, in vivo and in silico approaches
by: Raza H.; Abbasi M.A.; Aziz-ur-Rehman; Siddiqui S.Z.; Hassan M.; Abbas Q.; Hong H.; Shah S.A.A.; Shahid M.; Seo S.-Y.
Published: (2020)

Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies
by: Taha M.; Ismail N.H.; Imran S.; Ainaa I.; Selvaraj M.; baharudin M.; Ali M.; Khan K.M.; Uddin N.
Published: (2017)

In-silico molecular design of heterocyclic benzimidazole scaffolds as prospective anticancer agents
by: Tahlan S.; Kumar S.; Ramasamy K.; Lim S.M.; Shah S.A.A.; Mani V.; Narasimhan B.
Published: (2019)

Synthesis of new 2-{2,3-dihydro-1,4-benzodioxin-6-yl[(4‑methylphenyl) sulfonyl]amino}-N-(un/substituted-phenyl) acetamides as α-glucosidase and acetylcholinesterase inhibitors and their in silico study
by: Abbasi M.A.; Riaz S.; Aziz-Ur-rehman; Siddiqui S.Z.; Shah S.A.A.; Ashraf M.; Lodhi M.A.; Khan F.A.
Published: (2019)