Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study

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Discovery of Dual Inhibitors of Acetyl and Butrylcholinesterase and Antiproliferative Activity of 1,2,4-Triazole-3-thiol: Synthesis and In Silico Molecular Study

The aim of this current study is to discover effective acetyl and butrylcholinesterase enzyme inhibitors. A concise library of S-alkylated/arylated-4-ethyl-5-(4-methoxyphenyl)-4H-1,2,4-triazole-3-thiols 5–18 was synthesized by using a multistep reaction sequence. The compounds were characterized by...

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Bibliographic Details
Published in:	ChemistrySelect
Main Author:	Siddiqui S.Z.; Arfan M.; Abbasi M.A.; Aziz-ur-Rehman; Shah S.A.A.; Ashraf M.; Hussain S.; Saleem R.S.Z.; Rafique R.; Khan K.M.
Format:	Article
Language:	English
Published:	Wiley-Blackwell 2020
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85087042710&doi=10.1002%2fslct.201904905&partnerID=40&md5=d590998bb08f0019fbf72c99d821dd99

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