Novel Bi-heterocycles as potent inhibitors of Urease and less cytotoxic agents: 3-({5-((2-amino-1,3-thiazol-4-yl)methyl)-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl) propanamides

The synthesis of a novel series of bi-heterocyclic propanamides, 7a-l, was accomplished by S-substitution of 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-thiol (3). The synthesis was initiated from ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (1) which was converted to corresponding hydrazide...

Full description

Bibliographic Details
Published in:Iranian Journal of Pharmaceutical Research
Main Author: Abbasi M.A.; Ramzan M.S.; Aziz-Ur-Rehman; Siddiqui S.Z.; Hassan M.; Shah S.A.A.; Ashraf M.; Shahid M.; Seo S.-Y.
Format: Article
Language:English
Published: Iranian Journal of Pharmaceutical Research 2020
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085346036&doi=10.22037%2fijpr.2019.13084.11362&partnerID=40&md5=42f727fe97faa359f68a1c84b3a321a0