Novel Bi-heterocycles as potent inhibitors of Urease and less cytotoxic agents: 3-({5-((2-amino-1,3-thiazol-4-yl)methyl)-1,3,4-oxadiazol-2-yl}sulfanyl)-N-(un/substituted-phenyl) propanamides
The synthesis of a novel series of bi-heterocyclic propanamides, 7a-l, was accomplished by S-substitution of 5-[(2-amino-1,3-thiazol-4-yl)methyl]-1,3,4-oxadiazol-2-thiol (3). The synthesis was initiated from ethyl 2-(2-amino-1,3-thiazol-4-yl)acetate (1) which was converted to corresponding hydrazide...
| Published in: | Iranian Journal of Pharmaceutical Research |
|---|---|
| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Iranian Journal of Pharmaceutical Research
2020
|
| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85085346036&doi=10.22037%2fijpr.2019.13084.11362&partnerID=40&md5=42f727fe97faa359f68a1c84b3a321a0 |