Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease

Design, synthesis, in vitro evaluation, molecular docking and ADME properties studies of hybrid bis-coumarin with thiadiazole as a new inhibitor of Urease

Hybrid bis-coumarin derivatives 1–18 were synthesized and evaluated for their in vitro urease inhibitory potential. All compounds showed outstanding urease inhibitory potential with IC50 value (The half maximal inhibitory concentration) ranging in between 0.12 SD 0.01 and 38.04 SD 0.63 µM (SD standa...

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Bibliographic Details
Published in:Bioorganic Chemistry
Main Author: Alomari M.; Taha M.; Imran S.; Jamil W.; Selvaraj M.; Uddin N.; Rahim F.
Format: Article
Language:English
Published: Academic Press Inc. 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071689548&doi=10.1016%2fj.bioorg.2019.103235&partnerID=40&md5=7f6c163ed9319ed5d2e11fe81676b814

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https://www.scopus.com/inward/record.uri?eid=2-s2.0-85071689548&doi=10.1016%2fj.bioorg.2019.103235&partnerID=40&md5=7f6c163ed9319ed5d2e11fe81676b814

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