Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies

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Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies

In searchof the potenttherapeutic agent as an α-glucosidase inhibitor, we have synthesized twenty-five analogs (1–25) of quinoline-based Schiff bases as an inhibitoragainst α-glucosidase enzyme under positive control acarbose (IC50 = 38.45 ± 0.80 µM). From the activity profile it was foundthat analo...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Taha M.; Sultan S.; Imran S.; Rahim F.; Zaman K.; Wadood A.; Ur Rehman A.; Uddin N.; Mohammed Khan K.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069971619&doi=10.1016%2fj.bmc.2019.07.035&partnerID=40&md5=6c1dae4e50ca9d71d8e319c5e61a39dc

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