Synthesis of quinoline derivatives as diabetic II inhibitors and molecular docking studies
In searchof the potenttherapeutic agent as an α-glucosidase inhibitor, we have synthesized twenty-five analogs (1–25) of quinoline-based Schiff bases as an inhibitoragainst α-glucosidase enzyme under positive control acarbose (IC50 = 38.45 ± 0.80 µM). From the activity profile it was foundthat analo...
| Published in: | Bioorganic and Medicinal Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2019
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85069971619&doi=10.1016%2fj.bmc.2019.07.035&partnerID=40&md5=6c1dae4e50ca9d71d8e319c5e61a39dc |