Antinociceptive activity of petroleum ether fraction obtained from methanolic extract of Clinacanthus nutans leaves involves the activation of opioid receptors and NO-mediated/cGMP-independent pathway

Background: Methanol extract (MECN) of Clinacanthus nutans Lindau leaves (family Acanthaceae) demonstrated peripherally and centrally mediated antinociceptive activity via the modulation of opioid/NO-mediated, but cGMP-independent pathway. In the present study, MECN was sequentially partitioned to o...

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Bibliographic Details
Published in:BMC Complementary and Alternative Medicine
Main Author: Zakaria Z.A.; Abdul Rahim M.H.; Mohd Sani M.H.; Omar M.H.; Ching S.M.; Abdul Kadir A.; Ahmed Q.U.
Format: Article
Language:English
Published: BioMed Central Ltd. 2019
Online Access:https://www.scopus.com/inward/record.uri?eid=2-s2.0-85063801773&doi=10.1186%2fs12906-019-2486-8&partnerID=40&md5=d764576ae88c4afaa14f48f97f914a43