Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study

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Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study

We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC50 = 38.68 ± 4.42 µM). The most potent co...

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Bibliographic Details
Published in:	Molecules
Main Author:	Almandil N.B.; Taha M.; Farooq R.K.; Alhibshi A.; Ibrahim M.; Anouar E.H.; Gollapalli M.; Rahim F.; Nawaz M.; Shah S.A.A.; Ahmed Q.U.; Zakaria Z.A.
Format:	Article
Language:	English
Published:	MDPI AG 2019
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062955700&doi=10.3390%2fmolecules24061002&partnerID=40&md5=ef4631fe73f2a47cb1b36fec4203f36b

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