Synthesis of thymidine phosphorylase inhibitor based on quinoxaline derivatives and their molecular docking study
We have synthesized quinoxaline analogs (1–25), characterized by 1H-NMR and HREI-MS and evaluated for thymidine phosphorylase inhibition. Among the series, nineteen analogs showed better inhibition when compared with the standard inhibitor 7-Deazaxanthine (IC50 = 38.68 ± 4.42 µM). The most potent co...
| Published in: | Molecules |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2019
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85062955700&doi=10.3390%2fmolecules24061002&partnerID=40&md5=ef4631fe73f2a47cb1b36fec4203f36b |