Exploration of synthetic multifunctional amides as new therapeutic agents for Alzheimer's disease through enzyme inhibition, chemoinformatic properties, molecular docking and dynamic simulation insights
A new series of multifunctional amides has been synthesized having moderate enzyme inhibitory potentials and mild cytotoxicity. 2-Furyl(1-piperazinyl)methanone (1) was coupled with 3,5-dichloro-2-hydroxybenzenesulfonyl chloride (2) to form {4-[(3,5-dichloro-2-hydroxyphenyl)sulfonyl]-1-piperazinyl}(2...
| Published in: | Journal of Theoretical Biology |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Academic Press
2018
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85053905014&doi=10.1016%2fj.jtbi.2018.09.018&partnerID=40&md5=389296c4a0639983b208beb994df0448 |