Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives

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Synthesis, α-glucosidase inhibition and molecular docking study of coumarin based derivatives

We have synthesized seventeen Coumarin based derivatives (1–17), characterized by 1HNMR, 13CNMR and EI-MS and evaluated for α-glucosidase inhibitory potential. Among the series, all derivatives exhibited outstanding α-glucosidase inhibition with IC50 values ranging between 1.10 ± 0.01 and 36.46 ± 0....

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Bibliographic Details
Published in:	Bioorganic Chemistry
Main Author:	Taha M.; Shah S.A.A.; Afifi M.; Imran S.; Sultan S.; Rahim F.; Khan K.M.
Format:	Article
Language:	English
Published:	Academic Press Inc. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85042298379&doi=10.1016%2fj.bioorg.2018.01.033&partnerID=40&md5=5c35beb970165c041387e80b318fdd17

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