Intraocular pressure lowering effect and structure-activity relationship of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats: Insight on possible link with hypotensive activity

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Intraocular pressure lowering effect and structure-activity relationship of imidazo[1,2-a]benzimidazole and pyrimido[1,2-a]benzimidazole compounds in ocular normotensive rats: Insight on possible link with hypotensive activity

In an effort to find new ocular hypotensive drug candidates, a total of 27 condensed benzimidazoles based compounds were screened. This study was done in normotensive rats and rebound tonometry was used to estimate IOP. All compounds were topically applied as a single drop, unilaterally, at 3 differ...

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Bibliographic Details
Published in:	European Journal of Pharmaceutical Sciences
Main Author:	Marcus A.J.; Iezhitsa I.; Agarwal R.; Vassiliev P.; Spasov A.; Zhukovskaya O.; Anisimova V.; Johari B.; Mohd Ismail N.
Format:	Article
Language:	English
Published:	Elsevier B.V. 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85039419476&doi=10.1016%2fj.ejps.2017.12.015&partnerID=40&md5=217529effc66c759005dd8a9bc2b8792

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