Bisindolylmethane thiosemicarbazides as potential inhibitors of urease: Synthesis and molecular modeling studies

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Bisindolylmethane thiosemicarbazides as potential inhibitors of urease: Synthesis and molecular modeling studies

Bisindolylmethane thiosemicarbazides 1-18 were synthesized, characterized by 1H NMR and ESI MS and evaluated for urease inhibitory potential. All analogs showed outstanding urease inhibitory potentials with IC50 values ranging between 0.14 ± 0.01 to 18.50 ± 0.90 μM when compared with the standard in...

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Bibliographic Details
Published in:	Bioorganic and Medicinal Chemistry
Main Author:	Taha M.; Ullah H.; Al Muqarrabun L.M.R.; Khan M.N.; Rahim F.; Ahmat N.; Javid M.T.; Ali M.; Khan K.M.
Format:	Article
Language:	English
Published:	Elsevier Ltd 2018
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034860481&doi=10.1016%2fj.bmc.2017.11.028&partnerID=40&md5=0bd438fd799d4cfca58d108fa5f9d542

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