Bisindolylmethane thiosemicarbazides as potential inhibitors of urease: Synthesis and molecular modeling studies
Bisindolylmethane thiosemicarbazides 1-18 were synthesized, characterized by 1H NMR and ESI MS and evaluated for urease inhibitory potential. All analogs showed outstanding urease inhibitory potentials with IC50 values ranging between 0.14 ± 0.01 to 18.50 ± 0.90 μM when compared with the standard in...
| Published in: | Bioorganic and Medicinal Chemistry |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Elsevier Ltd
2018
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85034860481&doi=10.1016%2fj.bmc.2017.11.028&partnerID=40&md5=0bd438fd799d4cfca58d108fa5f9d542 |