Synthesis and pharmacological screening: Sulfa derivatives of 2-pipecoline-bearing 1,3,4-oxadiazole core

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Synthesis and pharmacological screening: Sulfa derivatives of 2-pipecoline-bearing 1,3,4-oxadiazole core

An electrophile, 1-(4-(bromomethylbenzenesulfonyl)-2-methylpiperidine, was synthesized by the reaction of 2-methylpiperidine (2-pipecoline) and 4-bromomethylbenzenesulfonyl chloride in a weak basic medium under pH control. A series of nucleophiles, 5-aryl/aralkyl-1,3,4-oxadiazol-2-thiols, were synth...

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Bibliographic Details
Published in:	Russian Journal of Bioorganic Chemistry
Main Author:	Aziz-ur-Rehman; Arif A.; Abbasi M.A.; Siddiqui S.Z.; Rasool S.; Shah S.A.A.
Format:	Article
Language:	English
Published:	Maik Nauka Publishing / Springer SBM 2017
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021450391&doi=10.1134%2fS1068162017030025&partnerID=40&md5=3eac25863f9bc97c4c1bf4915f182b67

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