Synthesis and pharmacological screening: Sulfa derivatives of 2-pipecoline-bearing 1,3,4-oxadiazole core
An electrophile, 1-(4-(bromomethylbenzenesulfonyl)-2-methylpiperidine, was synthesized by the reaction of 2-methylpiperidine (2-pipecoline) and 4-bromomethylbenzenesulfonyl chloride in a weak basic medium under pH control. A series of nucleophiles, 5-aryl/aralkyl-1,3,4-oxadiazol-2-thiols, were synth...
Published in: | Russian Journal of Bioorganic Chemistry |
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Main Author: | |
Format: | Article |
Language: | English |
Published: |
Maik Nauka Publishing / Springer SBM
2017
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Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85021450391&doi=10.1134%2fS1068162017030025&partnerID=40&md5=3eac25863f9bc97c4c1bf4915f182b67 |