Reduction of oxidative-nitrosative stress underlies anticataract effect of topically applied tocotrienol in streptozotocin-induced diabetic rats
Cataract, a leading cause of blindness, is of special concern in diabetics as it occurs at earlier onset. Polyol accumulation and increased oxidative-nitrosative stress in cataractogenesis are associated with NFκB activation, iNOS expression, ATP depletion, loss of ATPase functions, calpain activati...
| Published in: | PLoS ONE |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science
2017
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85016318980&doi=10.1371%2fjournal.pone.0174542&partnerID=40&md5=ad23ac5d9637ceadd9c6f57e8e337ecb |