Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies

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Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies

A series of imidazo[4,5-b]pyridines (3–32) was synthesized and evaluated for their ability to inhibit Baker’s yeast α-glucosidase enzyme. The IC50 values for all compounds were in the range of 13.5–93.7 µM with compound 15, a 2,4-dihydroxy-substituted analog, displayed the most potent activity poten...

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Bibliographic Details
Published in:	Medicinal Chemistry Research
Main Author:	Taha M.; Ismail N.H.; Imran S.; Ainaa I.; Selvaraj M.; baharudin M.; Ali M.; Khan K.M.; Uddin N.
Format:	Article
Language:	English
Published:	Birkhauser Boston 2017
Online Access:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013391815&doi=10.1007%2fs00044-017-1806-0&partnerID=40&md5=e8c3209c361d7eda884ae9fbda20aab4

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