Synthesis of 2-phenyl-1H-imidazo[4,5-b]pyridine as type 2 diabetes inhibitors and molecular docking studies
A series of imidazo[4,5-b]pyridines (3–32) was synthesized and evaluated for their ability to inhibit Baker’s yeast α-glucosidase enzyme. The IC50 values for all compounds were in the range of 13.5–93.7 µM with compound 15, a 2,4-dihydroxy-substituted analog, displayed the most potent activity poten...
| Published in: | Medicinal Chemistry Research |
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| Main Author: | |
| Format: | Article |
| Language: | English |
| Published: |
Birkhauser Boston
2017
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| Online Access: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85013391815&doi=10.1007%2fs00044-017-1806-0&partnerID=40&md5=e8c3209c361d7eda884ae9fbda20aab4 |